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Recombinant human stem cell factor, a c-kit ligand, stimulates
hematopoiesis in primates
RG Andrews, GH Knitter, SH Bartelmez, KE Langley, D Farrar, RW Hendren, FR Appelbaum, ID Bernstein and KM Zsebo
Department of Pediatric, Fred Hutchinson Cancer Research Center, Seattle,
WA 98104.
Recombinant human stem cell factor (SCF) is homologous with recombinant rat
SCF (rrSCF) and is a ligand for c-kit. We determined the influence of SCF
on hematopoiesis in vitro and in vivo in baboons. In vitro, SCF alone
stimulated little growth of hematopoietic colony-forming cells from baboon
marrow, but did increase the number of colonies formed in response to
erythropoietin (Epo), interleukin-3 (IL-3), and granulocyte- macrophage
colony-stimulating factor (GM-CSF). In vivo, SCF caused an increase in the
peripheral blood of the number of erythrocytes, neutrophils, lymphocytes,
monocytes, eosinophils, and basophils. In marrow, it caused an increase in
marrow cellularity and in the absolute number of colony-forming
unit-granulocyte-monocyte (CFU-GM) and burst- forming unit-erythroid
(BFU-E) in marrow following infusion of SCF. The in vivo stimulation of
multiple lymphohematopoietic lineages corroborates previous in vitro
studies and suggests a potentially important clinical role for SCF.
Volume 78,
Issue 8,
pp. 1975-1980,
10/15/1991
Copyright © 1991 by The American Society of Hematology
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