|
|
 Previous Article | Table of Contents | Next Article 
Follicular non-Hodgkin's lymphoma cell adhesion to normal germinal centers
and neoplastic follicles involves very late antigen-4 and vascular cell
adhesion molecule-1
AS Freedman, JM Munro, C Morimoto, BW McIntyre, K Rhynhart, N Lee and LM Nadler
Division of Tumor Immunology, Dana-Farber Cancer Institute, Boston, MA
02115.
Follicular lymphomas recapitulate the architecture of germinal centers
(GCs) of normal secondary lymphoid follicles. Using an in vitro binding
assay, it has recently been demonstrated that the normal B lymphocytes bind
to GCs. This interaction is mediated by a receptor-ligand pair consisting
of the beta 1 integrin very late antigen 4 (VLA-4) on the B cell, and the
vascular cell adhesion molecule-1 (VCAM-1) expressed on follicular
dendritic cells (FDC). Considering the similarities between follicular
lymphomas and normal GCs, the adhesive interaction of follicular
non-Hodgkin's lymphoma (NHL) cells and GCs was examined. Cells isolated
from 16 of 24 cases of follicular NHL bound to normal GCs. Neoplastic
follicles could similarly support the binding of follicular NHL cells. This
adhesion was inhibited by monoclonal antibodies (MoAbs) directed against
VLA-4 and VCAM-1. This supports the hypothesis that the neoplastic
follicles used the identical adhesive interactions responsible, at least in
part, for the localization of normal B cells to GCs. Adhesion receptors
have an important role in the regulation of normal lymphoid cell
proliferation, differentiation, and localization. Therefore, an
understanding of the adhesive interaction of follicular NHL cells with GCs
may provide insight into the clinical and biologic behavior of these
diseases.
Volume 79,
Issue 1,
pp. 206-212,
01/01/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. Rajashekhar, A. Loganath, A. C. Roy, and Y. C. Wong
Expression and Secretion of the Vascular Cell Adhesion Molecule-1 in Human Placenta and Its Decrease in Fetal Growth Restriction
Reproductive Sciences,
September 1, 2003;
10(6):
352 - 360.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. P. Vallely, P. G. Bannon, C. F. Hughes, and L. Kritharides
Endothelial expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 is suppressed by postbypass plasma containing increased soluble intercellular adhesion molecule 1 and vascular cell adhesion molecule 1
J. Thorac. Cardiovasc. Surg.,
October 1, 2002;
124(4):
758 - 767.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Husson, E. G. Carideo, D. Neuberg, J. Schultze, O. Munoz, P. W. Marks, J. W. Donovan, A. C. Chillemi, P. O'Connell, and A. S. Freedman
Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays
Blood,
January 1, 2002;
99(1):
282 - 289.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Corcione, L. Ottonello, G. Tortolina, P. Facchetti, I. Airoldi, R. Guglielmino, P. Dadati, M. Truini, S. Sozzani, F. Dallegri, et al.
Stromal Cell-Derived Factor-1 as a Chemoattractant for Follicular Center Lymphoma B Cells
J Natl Cancer Inst,
April 19, 2000;
92(8):
628 - 635.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Drillenburg and S. T. Pals
Cell adhesion receptors in lymphoma dissemination
Blood,
March 15, 2000;
95(6):
1900 - 1910.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. W. Kamel
Unraveling the Mystery of the Lymphoid Follicle
Am. J. Pathol.,
September 1, 1999;
155(3):
681 - 682.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-J. Terol, A. Lopez-Guillermo, F. Bosch, N. Villamor, M.-C. Cid, E. Campo, and E. Montserrat
Expression of Beta-Integrin Adhesion Molecules in Non-Hodgkin's Lymphoma: Correlation With Clinical and Evolutive Features
J. Clin. Oncol.,
June 1, 1999;
17(6):
1869 - 1869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Geissmann, A. Ruskone-Fourmestraux, O. Hermine, P. Bourquelot, C. Belanger, J. Audouin, A. Delmer, E. A. Macintyre, B. Varet, and N. Brousse
Homing Receptor {alpha}4ß7 Integrin Expression Predicts Digestive Tract Involvement in Mantle Cell Lymphoma
Am. J. Pathol.,
December 1, 1998;
153(6):
1701 - 1705.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hasegawa, T. Nomura, K. Kishimoto, K. Yanagisawa, and S. Fujita
SFA-1/PETA-3 (CD151), a Member of the Transmembrane 4 Superfamily, Associates Preferentially with {alpha}5{beta}1 Integrin and Regulates Adhesion of Human T Cell Leukemia Virus Type 1-Infected T Cells to Fibronectin
J. Immunol.,
September 15, 1998;
161(6):
3087 - 3095.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
