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Effect of nerve growth factor on the release of inflammatory mediators by
mature human basophils
SC Bischoff and CA Dahinden
Institute of Clinical Immunology, Inselspital, Bern, Switzerland.
Nerve growth factor (NGF) is a neurotrophic cytokine known to regulate the
survival and function of peripheral and central neuronal cells. Recently,
the spectrum of action could be extended to non-neuronal cell types such as
rat mast cells and human B lymphocytes. The present study shows that NGF
affects the function of mature human basophils isolated from the peripheral
blood of healthy donors. Both murine NGF 7S and recombinant human NGF beta
enhance histamine release and strongly modulate the formation of lipid
mediators by basophils in response to various stimuli. This priming effect
of NGF on basophils occurs rapidly within 10 to 15 minutes of
preincubation, is dose-dependent, and requires similarly low concentrations
(1 to 40 pmol/L) of human NGF beta as the induction of neurite outgrowth in
ganglion cells. Cell fractionation studies indicate that NGF acts directly
on human basophils without an involvement of other cell types, suggesting
the presence of high-affinity NGF receptors on basophils. NGF by itself (up
to 4 nmol/L of human NGF beta) does not induce the release of inflammatory
mediators directly. The effect of human NGF on basophil mediator release is
similar to that of the hematopoietic growth factors interleukin-3,
interleukin-5, and granulocyte-macrophage colony- stimulating factor. The
present study further demonstrates that NGF acts as a pleiotropic cytokine
at the interface between the nervous and the immune system, and that NGF
may be involved in inflammatory processes and hypersensitivity reactions.
Volume 79,
Issue 10,
pp. 2662-2669,
05/15/1992
Copyright © 1992 by The American Society of Hematology
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