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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Baldini, L. Articles by Maiolo, A. T. Search for Related Content PubMed PubMed Citation Articles by Baldini, L. Articles by Maiolo, A. T. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Differential expression of very late activation antigen-3 (VLA-3)/VLA-4 in B-cell non-Hodgkin lymphoma and B-cell chronic lymphocytic leukemia L Baldini, L Cro, R Calori, L Nobili, I Silvestris and AT Maiolo Department of Hematology, Centro G. Marcora, Ospedale Maggiore IRCCS, Milan, Italy. The expression of beta 1 (very late activation antigens, VLA 1-6) and beta 2 integrins (leukocyte adhesion molecules [Leu-CAM]) in cell suspensions from the peripheral blood of 70 patients with B-cell chronic lymphocytic leukemia (B-CLL), 15 patients with leukemic lymphocytic lymphoma of intermediate differentiation (IDL), as well as from the lymph nodes of 20 patients with low/intermediate-grade non- Hodgkin's lymphoma (NHL) was studied with the aim of characterizing their adhesive phenotype and evaluating its relationship to clinical behavior. CD11a(LFA-1) was more expressed in NHL and IDL than in B-CLL (P = .047), although it was demonstrable in 74.2% of cases; CD11c was more expressed in B-CLL (P less than .0001), and its expression was preserved in almost all of the cases of small lymphocytic lymphoma. In NHL patients, including the cases of IDL, VLA-3 expression was observable in 8 of 35 cases (although always at a low level of intensity), while VLA-4 was almost constantly expressed in a way that was similar to its expression in control normal B cells. On the contrary, in B-CLL patients, VLA-3 was expressed (prevalently at high levels) in 87.1% of cases and VLA-4 only in 37.1%. No correlation was found between adhesion molecule patterns and the clinical features of the diseases. The biofunctional significance of the imbalance of VLA-3 and VLA-4 expression in B-CLL is not easy to explain, but it has undoubted intrinsic value as an additional marker for distinguishing B- CLL from, in particular, those B-cell neoplasms (such as IDL) that share many of the immunocytomorphologic characteristics and the putative normal counterpart (the mantle zone) of B-CLL. Volume 79, Issue 10, pp. 2688-2693, 05/15/1992 Copyright © 1992 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. J. Till, K. Lin, M. Zuzel, and J. C. Cawley The chemokine receptor CCR7 and alpha 4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes Blood, April 15, 2002; 99(8): 2977 - 2984. [Abstract] [Full Text] [PDF] M.-J. Terol, A. Lopez-Guillermo, F. Bosch, N. Villamor, M.-C. Cid, E. Campo, and E. Montserrat Expression of Beta-Integrin Adhesion Molecules in Non-Hodgkin's Lymphoma: Correlation With Clinical and Evolutive Features J. Clin. Oncol., June 1, 1999; 17(6): 1869 - 1869. [Abstract] [Full Text] [PDF] S. Sembries, H. Pahl, S. Stilgenbauer, H. Dohner, and F. Schriever Reduced Expression of Adhesion Molecules and Cell Signaling Receptors by Chronic Lymphocytic Leukemia Cells With 11q Deletion Blood, January 15, 1999; 93(2): 624 - 631. [Abstract] [Full Text] [PDF]

	Copyright © 1992 by American Society of Hematology         Online ISSN: 1528-0020