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B-myb antisense oligonucleotides inhibit proliferation of human
hematopoietic cell lines
M Arsura, M Introna, F Passerini, A Mantovani and J Golay
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
The B-myb gene is highly homologous to the c-myb protooncogene in several
domains and also shares some of the functions of c-myb in that it can act
as a transcriptional activator. In addition, the expression of both the
B-myb and c-myb genes correlates with proliferation of normal hematopoietic
cells. We investigated more directly the role of B- myb in proliferation of
hematopoietic cell lines using B-myb-specific antisense oligonucleotides.
We showed that several anti-B-myb oligonucleotides, complementary to
distinct regions of the gene, inhibit significantly and in a dose-dependent
manner the proliferation of all myeloid or lymphoid cell lines tested. This
block in proliferation was not accompanied by detectable differentiation of
U937 or HL60 cells to macrophages or granulocytes either spontaneously or
after exposure to chemical agents. These data suggest that the B-myb gene,
like c-myb, is necessary for hematopoietic cell proliferation.
Volume 79,
Issue 10,
pp. 2708-2716,
05/15/1992
Copyright © 1992 by The American Society of Hematology
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81(5):
2102 - 2116.
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280(16):
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278(45):
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|
|
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100(13):
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[Full Text]
[PDF]
|
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|
|
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C Gaillard, E Le Rouzic, C Creminon, and B Perbal
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October 1, 2002;
55(5):
325 - 335.
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|
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X. Li and D. P. McDonnell
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June 1, 2002;
22(11):
3663 - 3673.
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|
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October 12, 2001;
276(42):
39171 - 39178.
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|
|
|
|
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|
|
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April 1, 2001;
97(7):
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|
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|
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275(14):
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|
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275(9):
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|
|
|
|
|
|
|
T. K. Johnson, R. E. Schweppe, J. Septer, and R. E. Lewis
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274(51):
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|
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|
|
|
|
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274(40):
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[Full Text]
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|
|
|
|
|
|
|
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160(6):
2786 - 2793.
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|
|
|
|
|
|
|
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18(1):
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|
|
|
|
|
|
|
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272(40):
24921 - 24926.
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[Full Text]
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|
|
|
|
|
|
|
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January 21, 1997;
94(2):
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[Full Text]
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|
|
|
|
|
|
|
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271(46):
28738 - 28740.
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[Full Text]
[PDF]
|
|
|
|
|
|
|
D Taylor, P Badiani, and K Weston
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Genes & Dev.,
November 1, 1996;
10(21):
2732 - 2744.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Sala, I. Casella, T. Bellon, B. Calabretta, R. J. Watson, and C. Peschle
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J. Biol. Chem.,
April 19, 1996;
271(16):
9363 - 9367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Locati, G. Lamorte, W. Luini, M. Introna, S. Bernasconi, A. Mantovani, and S. Sozzani
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J. Biol. Chem.,
March 15, 1996;
271(11):
6010 - 6016.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. J. Marhamati and G. E. Sonenshein
B-Myb Expression in Vascular Smooth Muscle Cells Occurs in a Cell Cycle-dependent Fashion and Down-regulates Promoter Activity of Type I Collagen Genes
J. Biol. Chem.,
February 16, 1996;
271(7):
3359 - 3365.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Raschell, A. Negroni, A. Sala, S. Pucci, A. Romeo, and B. Calabretta
Requirement of B- myb Function for Survival and Differentiative Potential of Human Neuroblastoma Cells
J. Biol. Chem.,
April 14, 1995;
270(15):
8540 - 8545.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Stein and Y. Cheng
Antisense oligonucleotides as therapeutic agents--is the bullet really magical?
Science,
August 20, 1993;
261(5124):
1004 - 1012.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Cervellera, G. Raschella, G. Santilli, B. Tanno, A. Ventura, C. Mancini, C. Sevignani, B. Calabretta, and A. Sala
Direct Transactivation of the Anti-apoptotic Gene Apolipoprotein J (Clusterin) by B-MYB
J. Biol. Chem.,
July 7, 2000;
275(28):
21055 - 21060.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
