|
|
 Previous Article | Table of Contents | Next Article 
Suppressive effect of granulocyte-macrophage colony-stimulating factor on
the generation of natural killer cells in vitro
K Taguchi, A Shibuya, Y Inazawa and T Abe
Division of Hematology, University of Tsukuba, Ibaraki, Japan.
We investigated the effects of recombinant human granulocyte-macrophage
colony-stimulating factor (rhGM-CSF) and recombinant human granulocyte- CSF
(rhG-CSF) on the generation of natural killer (NK) cells in vitro. NK cells
were cultured from selected human bone marrow cells obtained after the
elimination of mature T and NK cells. rhGM-CSF significantly suppressed the
generation of CD56+ cells and NK activity (P less than .01) in a
dose-dependent manner. The generation of large granular lymphocytes (LGL)
was also suppressed in the presence of rhGM-CSF (P less than .01). In
contrast, rhG-CSF had no effect on LGL (P greater than .05). Both rhGM-CSF
and rhG-CSF had no influence on the CD56+ cell count in the peripheral
blood. These results suggest that rhGM-CSF suppresses the in vitro
generation of NK cells.
Volume 79,
Issue 12,
pp. 3227-3232,
06/15/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. Stagg, J. H. Wu, N. Bouganim, and J. Galipeau
Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-2 Fusion cDNA for Cancer Gene Immunotherapy
Cancer Res.,
December 15, 2004;
64(24):
8795 - 8799.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Xu, R. Lucas, M. Schuchmann, S. Kuhnle, T. Meergans, A. P. Barreiros, A. W. Lohse, G. Otto, and A. Wendel
GM-CSF Restores Innate, But Not Adaptive, Immune Responses in Glucocorticoid-Immunosuppressed Human Blood In Vitro
J. Immunol.,
July 15, 2003;
171(2):
938 - 947.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Giron-Michel, M. Fogli, A. Gaggero, S. Ferrini, A. Caignard, D. Brouty-Boye, S. Baouz, M.-C. Le Bousse-Kerdiles, B. Peault, M. van Dijk, et al.
Detection of a Functional Hybrid Receptor {gamma}c/GM-CSFR{beta} in Human Hematopoietic CD34+ Cells
J. Exp. Med.,
March 17, 2003;
197(6):
763 - 775.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Gazitt
Immunologic Profiles of Effector Cells and Peripheral Blood Stem Cells Mobilized with Different Hematopoietic Growth Factors
Stem Cells,
November 1, 2000;
18(6):
390 - 398.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. S. Miller, F. Prosper, and V. McCullar
Natural Killer (NK) Cells Are Functionally Abnormal and NK Cell Progenitors Are Diminished in Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood Progenitor Cell Collections
Blood,
October 15, 1997;
90(8):
3098 - 3105.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
