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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Rinder, C. S. Articles by Smith, B. R. Search for Related Content PubMed PubMed Citation Articles by Rinder, C. S. Articles by Smith, B. R. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Cardiopulmonary bypass induces leukocyte-platelet adhesion CS Rinder, JL Bonan, HM Rinder, J Mathew, R Hines and BR Smith Department of Anesthesiology, Yale University School of Medicine, New Haven, CT 06510. Cardiopulmonary bypass (CPB) has been demonstrated to activate platelets, producing an increased number of circulating platelets that have undergone alpha-granule release and express granule membrane protein-140 (GMP-140) on their surface. In vitro, GMP-140 mediates activated platelet adhesion to neutrophils (PMN) and monocytes, causing the formation of leukocyte-platelet conjugates. Using a newly developed assay that measures the percentage of circulating leukocyte-platelet conjugates in whole blood, we studied 17 patients undergoing CPB and have determined that (1) monocyte-platelet conjugates increased significantly during CPB, from 18% +/- 1.5% to 44% +/- 4.5% (mean +/- SEM) by the end of CPB, while PMN-platelet conjugates increased only slightly and lymphocyte-platelet conjugates decreased; (2) the time course of the increase in monocyte- and PMN-platelet conjugates paralleled that of the increase in circulating activated platelets, as determined by the presence of surface GMP-140; and (3) monocyte activation, as assessed by increased surface expression of CD11b, showed a gradual increase similar to the increase in monocyte-platelet conjugates, while PMN surface CD11b peaked immediately after the start of CPB. We conclude that CPB, through increased platelet GMP-140 expression, causes formation of monocyte-platelet, and to a lesser extent, PMN-platelet conjugates. The activation of monocytes and PMN on CPB, as evidenced by CD11b expression, occurs with differing time courses. Volume 79, Issue 5, pp. 1201-1205, 03/01/1992 Copyright © 1992 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: P. Saravanan, A. R. Exley, K. Valchanov, N. D. Casey, and F. Falter Impact of xenon anaesthesia in isolated cardiopulmonary bypass on very early leucocyte and platelet activation and clearance: a randomized, controlled study Br. J. Anaesth., December 1, 2009; 103(6): 805 - 810. [Abstract] [Full Text] [PDF] E. Pluskota, N. M. Woody, D. Szpak, C. M. Ballantyne, D. A. Soloviev, D. I. Simon, and E. F. 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[Abstract] [Full Text] [PDF] G. J. Despotis, M. S. Avidan, and C. W. Hogue Jr Mechanisms and attenuation of hemostatic activation during extracorporeal circulation Ann. Thorac. Surg., November 1, 2001; 72(5): S1821 - 1831. [Abstract] [Full Text] [PDF] K. Kottke-Marchant and S. Sapatnekar Hemostatic Abnormalities in Cardiopulmonary Bypass: Pathophysiologic and Transfusion Considerations Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 187 - 206. [Abstract] [PDF] E. Appachi and E. B. Mossad Inflammatory Mediators and S-100{beta} Protein Concentrations in Neonates and Infants With Congenital Heart Disease Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2001; 5(3): 256 - 261. [Abstract] [PDF] I. Nupponen, S. Andersson, A.-L. Jarvenpaa, H. Kautiainen, and H. Repo Neutrophil CD11b Expression and Circulating Interleukin-8 as Diagnostic Markers for Early-Onset Neonatal Sepsis Pediatrics, July 1, 2001; 108(1): e12 - 12. 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Cell Biol., May 1, 2000; 149(3): 719 - 730. [Abstract] [Full Text] [PDF] J. C. K. Fitch, S. Rollins, L. Matis, B. Alford, S. Aranki, C. D. Collard, M. Dewar, J. Elefteriades, R. Hines, G. Kopf, et al. Pharmacology and Biological Efficacy of a Recombinant, Humanized, Single-Chain Antibody C5 Complement Inhibitor in Patients Undergoing Coronary Artery Bypass Graft Surgery With Cardiopulmonary Bypass Circulation, December 21, 1999; 100(25): 2499 - 2506. [Abstract] [Full Text] [PDF] C. S. Rinder, H. M. Rinder, M. J. Smith, J. B. Tracey, J. Fitch, L. Li, S. A. Rollins, and B. R. Smith SELECTIVE BLOCKADE OF MEMBRANE ATTACK COMPLEX FORMATION DURING SIMULATED EXTRACORPOREAL CIRCULATION INHIBITS PLATELET BUT NOT LEUKOCYTE ACTIVATION J. Thorac. Cardiovasc. Surg., September 1, 1999; 118(3): 460 - 466. [Abstract] [Full Text] [PDF] C. S. Rinder, H. M. Rinder, K. Johnson, M. Smith, D. L. Lee, J. Tracey, G. Polack, P. Higgins, C. G. Yeh, and B. R. Smith MD Role of C3 Cleavage in Monocyte Activation During Extracorporeal Circulation Circulation, August 3, 1999; 100(5): 553 - 558. [Abstract] [Full Text] [PDF] Y. Suzuki, R. Malekan, C. W. Hanson III, S. Niewiarowski, L. Sun, A. K. Rao, and L. H. Edmunds Jr PLATELET ANESTHESIA WITH NITRIC OXIDE WITH OR WITHOUT EPTIFIBATIDE DURING CARDIOPULMONARY BYPASS IN BABOONS J. Thorac. Cardiovasc. Surg., May 1, 1999; 117(5): 987 - 993. [Abstract] [Full Text] [PDF] P. Bugajski, R. Kalawski, I. Zurawska, M. Bartkowiak, H. Wysocki, R. Olszewski, and T. Siminiak Endothelin-1 is involved in plasma mediated stimulation of neutrophil adherence during coronary artery bypass grafting Eur. J. Cardiothorac. Surg., April 1, 1999; 15(4): 408 - 412. [Abstract] [Full Text] [PDF] S. Zahler, P. Massoudy, H. Hartl, C. Hahnel, H. Meisner, and B. F Becker Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass Cardiovasc Res, March 1, 1999; 41(3): 722 - 730. [Abstract] [Full Text] [PDF] F. Ichinose, S. Uezono, R. Muto, H. Uchida, F. Hatori, K. Terui, Y. Niimi, T. Goto, Y. Nakata, and S. Morita Platelet Hyporeactivity in Young Infants During Cardiopulmonary Bypass Anesth. Analg., February 1, 1999; 88(2): 258 - 258. [Abstract] [Full Text] [PDF] J. K. Mickelson, M. N. Ali, N. S. Kleiman, N. M. Lakkis, T. W. Chow, B. J. Hughes, and C. W. Smith Chimeric 7e3 Fab (ReoPro) decreases detectable CD11b on neutrophils from patients undergoing coronary angioplasty J. Am. Coll. Cardiol., January 1, 1999; 33(1): 97 - 106. [Abstract] [Full Text] [PDF] G. Asimakopoulos and K. M. Taylor Effects of cardiopulmonary bypass on leukocyte and endothelial adhesion molecules Ann. Thorac. Surg., December 1, 1998; 66(6): 2135 - 2144. [Abstract] [Full Text] [PDF] A. Weerasinghe and K. M. Taylor The platelet in cardiopulmonary bypass Ann. Thorac. Surg., December 1, 1998; 66(6): 2145 - 2152. [Abstract] [Full Text] [PDF] K. Konstantopoulos, S. Neelamegham, A. R. Burns, E. Hentzen, G. S. Kansas, K. R. Snapp, E. L. Berg, J. D. Hellums, C. W. Smith, L. V. McIntire, et al. Venous Levels of Shear Support Neutrophil-Platelet Adhesion and Neutrophil Aggregation in Blood via P-Selectin and ß2-Integrin Circulation, September 1, 1998; 98(9): 873 - 882. [Abstract] [Full Text] [PDF] C. R. Wilhelm, J. Ristich, R. L. Kormos, and W. R. Wagner Monocyte Tissue Factor Expression and Ongoing Complement Generation in Ventricular Assist Device Patients Ann. Thorac. Surg., April 1, 1998; 65(4): 1071 - 1076. [Abstract] [Full Text] [PDF] D. S. Morse, D. Adams, and B. Magnani Platelet and Neutrophil Activation During Cardiac Surgical Procedures: Impact of Cardiopulmonary Bypass Ann. Thorac. Surg., March 1, 1998; 65(3): 691 - 695. [Abstract] [Full Text] [PDF] W. J. Dreyer, A. R. Burns, S. C. Phillips, M. L. Lindsey, P. Jackson, and G. L. Kukielka Intercellular Adhesion Molecule-1 Regulation In The Canine Lung After Cardiopulmonary Bypass J. Thorac. Cardiovasc. Surg., March 1, 1998; 115(3): 689 - 693. [Abstract] [Full Text] [PDF] H. M. Rinder, J. E. Schuster, C. S. Rinder, C. Wang, H. J. Schweidler, and B. R. Smith Correlation of Thrombosis With Increased Platelet Turnover in Thrombocytosis Blood, February 15, 1998; 91(4): 1288 - 1294. [Abstract] [Full Text] [PDF] T. G. Diacovo, M. D. Catalina, M. H. Siegelman, and U. H. v. Andrian Circulating Activated Platelets Reconstitute Lymphocyte Homing and Immunity in L-selectin-Deficient Mice J. Exp. Med., January 19, 1998; 187(2): 197 - 204. [Abstract] [Full Text] [PDF] R. Pifarre Use of Aprotinin in the Control of Bleeding During Cardiopulmonary Bypass Surgery: Current Status Clinical and Applied Thrombosis/Hemostasis, January 1, 1998; 4(1): 2 - 6. [Abstract] [PDF] J. Joseph, P. Harrison, I. Mackie, and S.J. Machin Review : Platelet activation markers and the primary antiphospholipid syndrome (PAPS) Lupus, January 1, 1998; 7(2_suppl): S48 - S51. [Abstract] [PDF] A. Kumar, J. L. Hoover, C. A. Simmons, V. Lindner, and R. J. Shebuski Remodeling and Neointimal Formation in the Carotid Artery of Normal and P-Selectin–Deficient Mice Circulation, December 16, 1997; 96(12): 4333 - 4342. [Abstract] [Full Text] M. TSUCHIDA, H. WATANABE, T. WATANABE, H. HIRAHARA, M. HAGA, H. OHZEKI, J. HAYASHI, H. MIYAMURA, T. HIRONO, T. ABO, et al. Effect of Cardiopulmonary Bypass on Cytokine Release and Adhesion Molecule Expression in Alveolar Macrophages . Preliminary Report In Six Cases Am. J. Respir. Crit. Care Med., September 1, 1997; 156(3): 932 - 938. [Abstract] [Full Text] [PDF] F.-J. Neumann, N. Marx, M. Gawaz, K. Brand, I. Ott, C. Rokitta, C. Sticherling, C. Meinl, A. May, and A. Schomig Induction of Cytokine Expression in Leukocytes by Binding of Thrombin-Stimulated Platelets Circulation, May 20, 1997; 95(10): 2387 - 2394. [Abstract] [Full Text] C. Baufreton, P. Le Besnerais, P. Jansen, J. P. Mazzucotelli, C. R. Wildevuur, and D. Y Loisance Clinical outcome after coronary surgery with heparin-coated extracorporeal circuits for cardiopulmonary bypass Perfusion, November 1, 1996; 11(6): 437 - 443. [Abstract] [PDF] I. Ott, F.-J. Neumann, M. Gawaz, M. Schmitt, and A. Schomig Increased Neutrophil-Platelet Adhesion in Patients With Unstable Angina Circulation, September 15, 1996; 94(6): 1239 - 1246. [Abstract] [Full Text] C. Primack, J. M. Walenga, M. J. Koza, T. V. Shankey, and R. Pifarre Aprotinin Modulation of Platelet Activation in Patients Undergoing Cardiopulmonary Bypass Operations Ann. Thorac. Surg., April 1, 1996; 61(4): 1188 - 1193. [Abstract] [Full Text] P. Thurlow, L. Doolan, R. Sharp, M. Sullivan, B. Smith, and L. Andersen Laboratory studies of the effect of Pall extracorporeal leucocyte filters LG6 and AV6 on patients undergoing coronary bypass grafts Perfusion, January 1, 1996; 11(1): 29 - 37. [Abstract] [PDF] W. J. Dreyer, L. H. Michael, E. E. Millman, K. L. Berens, and R. S. Geske Neutrophil Sequestration and Pulmonary Dysfunction in a Canine Model of Open Heart Surgery With Cardiopulmonary Bypass : Evidence for a CD18-Dependent Mechanism Circulation, October 15, 1995; 92(8): 2276 - 2283. [Abstract] [Full Text] B. M. Steinberg, E. A. Grossi, D. S. Schwartz, D. E. McLoughlin, M. Aguinaga, C. Bizekis, J. Greenwald, A. Flisser, F. C. Spencer, A. C. Galloway, et al. Heparin Bonding of Bypass Circuits Reduces Cytokine Release During Cardiopulmonary Bypass Ann. Thorac. Surg., September 1, 1995; 60(3): 525 - 529. [Abstract] [Full Text] J. P. Mathew, C. S. Rinder, J. B. Tracey, L. A. Auszura, T. O'Connor, E. Davis, and B. R. Smith Acadesine inhibits neutrophil CD11b up-regulation in vitro and during in vivo cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., March 1, 1995; 109(3): 448 - 456. [Abstract] [Full Text] P. M. Kilbridge, J. E. Mayer, J. W. Newburger, P. R. Hickey, A. Z. Walsh, and E. J. Neufeld Induction of intercellular adhesion molecule-1 and E-selectin mRNA in heart and skeletal muscle of pediatric patients undergoing cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1183 - 1192. [Abstract] [Full Text] C. S. Rinder, D. Gaal, L. A. Student, and B. R. Smith Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., January 1, 1994; 107(1): 280 - 288. [Abstract] [Full Text] D. A Palanzo, N. J Manley, R. M Montesano, G. L Yeisley, and D. Gordon Clinical evaluation of the LeukoGuard (LG-6) arterial line filter for routine open-heart surgery Perfusion, November 1, 1993; 8(6): 489 - 496. [Abstract] [PDF]

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