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Enhanced expression of the tie receptor tyrosine kinase in endothelial
cells during neovascularization
J Korhonen, J Partanen, E Armstrong, A Vaahtokari, K Elenius, M Jalkanen and K Alitalo
Department of Pathology, University of Helsinki, Finland.
We have recently cloned a novel human receptor tyrosine kinase, tie, from
human leukemia cells showing megakaryoblastoid differentiation. We report
here that the 4.4-kb tie messenger RNA (mRNA) is present in all human fetal
and mouse embryonic tissues. By in situ hybridization, the tie mRNA was
localized to the endothelia of blood vessels and endocardium of 9.5- to
18.5-day mouse embryos. However, tie was not expressed by endothelial cells
of developing hepatic sinusoids. Increased tie mRNA signal was seen in
proliferating ovarial capillaries during hormone-induced superovulation.
Only a weak tie signal was obtained from adult skin, except during wound
healing, when the proliferating capillaries in the granulation tissue
contained abundant tie RNA. These results suggest that tie may have a role
in neovascularization.
Volume 80,
Issue 10,
pp. 2548-2555,
11/15/1992
Copyright © 1992 by The American Society of Hematology
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