|
|
 Previous Article | Table of Contents | Next Article 
Primary dexamethasone treatment of multiple myeloma
R Alexanian, MA Dimopoulos, K Delasalle and B Barlogie
University of Texas M.D. Anderson Cancer Center, Houston 77030.
Intermittent courses of dexamethasone (DEX) were administered to 112
consecutive, previously untreated patients with multiple myeloma (MM).
Using criteria based on a 75% or greater reduction of calculated tumor
mass, the overall response rate was 43%. Among comparable patients,
response rate were approximately 15% less than those observed previously
with vincristine-doxorubicin by continuous infusion with intermittent DEX
(VAD) and similar to those with melphalan-prednisone. The projected
survival times with VAD or DEX were similar. Results indicated that DEX
accounted for most of the plasma cell reduction achieved with VAD. Serious
complications occurred in 27% of patients treated with VAD, but in only 4%
of those who received DEX. In view of the similar outcome with fewer
serious complications, DEX provided a simple, effective, and safe primary
treatment for a large fraction of patients with MM. Patients who appear
most likely to benefit include those with hypercalcemia or pancytopenia, or
who require simultaneous radiotherapy for a pathologic fracture.
Volume 80,
Issue 4,
pp. 887-890,
08/15/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
S. K. Kumar, J. R. Mikhael, F. K. Buadi, D. Dingli, A. Dispenzieri, R. Fonseca, M. A. Gertz, P. R. Greipp, S. R. Hayman, R. A. Kyle, et al.
Management of Newly Diagnosed Symptomatic Multiple Myeloma: updated Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) Consensus Guidelines
Mayo Clin. Proc.,
December 1, 2009;
84(12):
1095 - 1110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. G. Richardson, W. Xie, C. Mitsiades, A. A. Chanan-Khan, S. Lonial, H. Hassoun, D. E. Avigan, A. L. Oaklander, D. J. Kuter, P. Y. Wen, et al.
Single-Agent Bortezomib in Previously Untreated Multiple Myeloma: Efficacy, Characterization of Peripheral Neuropathy, and Molecular Correlations With Response and Neuropathy
J. Clin. Oncol.,
July 20, 2009;
27(21):
3518 - 3525.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Niesvizky, D. S. Jayabalan, P. J. Christos, J. R. Furst, T. Naib, S. Ely, J. Jalbrzikowski, R. N. Pearse, F. Zafar, K. Pekle, et al.
BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma.
Blood,
February 1, 2008;
111(3):
1101 - 1109.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Rosinol, A. Oriol, M. V. Mateos, A. Sureda, P. Garcia-Sanchez, N. Gutierrez, A. Alegre, J. J. Lahuerta, J. de la Rubia, C. Herrero, et al.
Phase II Pethema Trial of Alternating Bortezomib and Dexamethasone As Induction Regimen Before Autologous Stem-Cell Transplantation in Younger Patients With Multiple Myeloma: Efficacy and Clinical Implications of Tumor Response Kinetics
J. Clin. Oncol.,
October 1, 2007;
25(28):
4452 - 4458.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Kastritis, A. Anagnostopoulos, M. Roussou, D. Gika, C. Matsouka, D. Barmparousi, I. Grapsa, E. Psimenou, A. Bamias, and M. A. Dimopoulos
Reversibility of renal failure in newly diagnosed multiple myeloma patients treated with high dose dexamethasone-containing regimens and the impact of novel agents
Haematologica,
April 1, 2007;
92(4):
546 - 549.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Dispenzieri, S. V. Rajkumar, M. A. Gertz, M. Q. Lacy, R. A. Kyle, P. R. Greipp, T. E. Witzig, J. A. Lust, S. J. Russell, S. R. Hayman, et al.
Treatment of Newly Diagnosed Multiple Myeloma Based on Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART): Consensus Statement
Mayo Clin. Proc.,
March 1, 2007;
82(3):
323 - 341.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. G. Mazzucconi, P. Fazi, S. Bernasconi, G. De Rossi, G. Leone, L. Gugliotta, N. Vianelli, G. Avvisati, F. Rodeghiero, A. Amendola, et al.
Therapy with high-dose dexamethasone (HD-DXM) in previously untreated patients affected by idiopathic thrombocytopenic purpura: a GIMEMA experience
Blood,
February 15, 2007;
109(4):
1401 - 1407.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. B. Baughn, M. Di Liberto, K. Wu, P. L. Toogood, T. Louie, R. Gottschalk, R. Niesvizky, H. Cho, S. Ely, M. A.S. Moore, et al.
A novel orally active small molecule potently induces g1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6.
Cancer Res.,
August 1, 2006;
66(15):
7661 - 7667.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Facon, J.-Y. Mary, B. Pegourie, M. Attal, M. Renaud, A. Sadoun, L. Voillat, V. Dorvaux, C. Hulin, G. Lepeu, et al.
Dexamethasone-based regimens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy
Blood,
February 15, 2006;
107(4):
1292 - 1298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. V. Rajkumar, E. Blood, D. Vesole, R. Fonseca, and P. R. Greipp
Phase III Clinical Trial of Thalidomide Plus Dexamethasone Compared With Dexamethasone Alone in Newly Diagnosed Multiple Myeloma: A Clinical Trial Coordinated by the Eastern Cooperative Oncology Group
J. Clin. Oncol.,
January 20, 2006;
24(3):
431 - 436.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Richardson and K. Anderson
Thalidomide and Dexamethasone: A New Standard of Care for Initial Therapy in Multiple Myeloma
J. Clin. Oncol.,
January 20, 2006;
24(3):
334 - 336.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. V. Rajkumar, S. R. Hayman, M. Q. Lacy, A. Dispenzieri, S. M. Geyer, B. Kabat, S. R. Zeldenrust, S. Kumar, P. R. Greipp, R. Fonseca, et al.
Combination therapy with lenalidomide plus dexamethasone (Rev/Dex) for newly diagnosed myeloma
Blood,
December 15, 2005;
106(13):
4050 - 4053.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. W. Lane, D. Gill, P. N. Mollee, and S. V. Rajkumar
Role of VAD in the initial treatment of multiple myeloma
Blood,
November 15, 2005;
106(10):
3674 - 3675.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. V. Rajkumar and R. A. Kyle
Multiple Myeloma: Diagnosis and Treatment
Mayo Clin. Proc.,
October 1, 2005;
80(10):
1371 - 1382.
[Abstract]
[PDF]
|
|
|
|
|
|
|
P. G. Richardson, P. Sonneveld, M. W. Schuster, D. Irwin, E. A. Stadtmauer, T. Facon, J.-L. Harousseau, D. Ben-Yehuda, S. Lonial, H. Goldschmidt, et al.
Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma
N. Engl. J. Med.,
June 16, 2005;
352(24):
2487 - 2498.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Tassone, P. Neri, R. Burger, R. Savino, M. Shammas, L. Catley, K. Podar, D. Chauhan, S. Masciari, A. Gozzini, et al.
Combination Therapy with Interleukin-6 Receptor Superantagonist Sant7 and Dexamethasone Induces Antitumor Effects in a Novel SCID-hu In vivo Model of Human Multiple Myeloma
Clin. Cancer Res.,
June 1, 2005;
11(11):
4251 - 4258.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Kyle and S. V. Rajkumar
Multiple Myeloma
N. Engl. J. Med.,
October 28, 2004;
351(18):
1860 - 1873.
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Wang, M. H. Malone, H. He, K. S. McColl, and C. W. Distelhorst
Microarray Analysis Uncovers the Induction of the Proapoptotic BH3-only Protein Bim in Multiple Models of Glucocorticoid-induced Apoptosis
J. Biol. Chem.,
June 20, 2003;
278(26):
23861 - 23867.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Liu, S. Hilsenbeck, and Y. Gazitt
Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL
Blood,
May 15, 2003;
101(10):
4078 - 4087.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Q. Liu and Y. Gazitt
Potentiation of dexamethasone-, paclitaxel-, and Ad-p53-induced apoptosis by Bcl-2 antisense oligodeoxynucleotides in drug-resistant multiple myeloma cells
Blood,
May 15, 2003;
101(10):
4105 - 4114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Weber, K. Rankin, M. Gavino, K. Delasalle, and R. Alexanian
Thalidomide Alone or With Dexamethasone for Previously Untreated Multiple Myeloma
J. Clin. Oncol.,
January 1, 2003;
21(1):
16 - 19.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. V. Rajkumar, S. Hayman, M. A. Gertz, A. Dispenzieri, M. Q. Lacy, P. R. Greipp, S. Geyer, N. Iturria, R. Fonseca, J. A. Lust, et al.
Combination Therapy With Thalidomide Plus Dexamethasone for Newly Diagnosed Myeloma
J. Clin. Oncol.,
November 1, 2002;
20(21):
4319 - 4323.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Gojo, B. Zhang, and R. G. Fenton
The Cyclin-dependent Kinase Inhibitor Flavopiridol Induces Apoptosis in Multiple Myeloma Cells through Transcriptional Repression and Down-Regulation of Mcl-1
Clin. Cancer Res.,
November 1, 2002;
8(11):
3527 - 3538.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. V. Rajkumar, M. A. Gertz, R. A. Kyle, P. R. Greipp, and Mayo Clinic Myeloma, Amyloid, and Dysproteinemia G
Current Therapy for Multiple Myeloma
Mayo Clin. Proc.,
August 1, 2002;
77(8):
813 - 822.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Alexanian, D. Weber, S. Giralt, and K. Delasalle
Consolidation therapy of multiple myeloma with thalidomide-dexamethasone after intensive chemotherapy
Ann. Onc.,
July 1, 2002;
13(7):
1116 - 1119.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. R. Berenson, J. J. Crowley, T. M. Grogan, J. Zangmeister, A. D. Briggs, G. M. Mills, B. Barlogie, and S. E. Salmon
Maintenance therapy with alternate-day prednisone improves survival in multiple myeloma patients
Blood,
May 1, 2002;
99(9):
3163 - 3168.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. de Lange, C. M. Segeren, J. W. Koper, E. Wiemer, P. Sonneveld, A. O. Brinkmann, A. White, I. J. Brogan, F. H. de Jong, and S. W. J. Lamberts
Expression in Hematological Malignancies of a Glucocorticoid Receptor Splice Variant That Augments Glucocorticoid Receptor-mediated Effects in Transfected Cells
Cancer Res.,
May 1, 2001;
61(10):
3937 - 3941.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
S. Kishi, N. Goto, T. Nakamura, and T. Ueda
Evaluation of Cell-killing Effects of 1-{beta}-D-Arabinofuranosylcytosine and Daunorubicin by a New Computer-controlled in Vitro Pharmacokinetic Simulation System
Cancer Res.,
June 1, 1999;
59(11):
2629 - 2634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Alexanian and M. Dimopoulos
The Treatment of Multiple Myeloma
N. Engl. J. Med.,
February 17, 1994;
330(7):
484 - 489.
[Full Text]
|
|
|
|
|
|
|
C. E. Dunbar and A. W. Nienhuis
Multiple Myeloma: New Approaches to Therapy
JAMA,
May 12, 1993;
269(18):
2412 - 2416.
[Abstract]
[PDF]
|
|
|
|
|
