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Detection of human T-cell leukemia/lymphoma virus, type II, in a patient
with large granular lymphocyte leukemia
TP Loughran , T Coyle, MP Sherman, G Starkebaum, GD Ehrlich, FW Ruscetti and BJ Poiesz
Fred Hutchinson Cancer Research Center, Seattle, WA.
We studied a patient with large granular lymphocyte (LGL) leukemia for
evidence of human T-cell leukemia/lymphoma virus (HTLV) infection. Serum
from this patient was positive for HTLV-I/II antibodies by enzyme- linked
immunosorbent assay (ELISA) and was confirmed positive in Western blot and
radioimmunoprecipitation assays. Results of a synthetic peptide-based ELISA
showed that the seropositivity was caused by HTLV-II and not HTLV-I
infection. Analyses of enzymatic amplification of DNA from bone marrow
sections using the polymerase chain reaction (PCR) were positive for
HTLV-II specific gag, pol, env, and pX gene sequences. Cloning and
sequencing of amplified products showed that the HTLV-II pol and pX
sequences in patient DNA differed from the sequences of 17 other HTLV-II
isolates examined in our laboratory. HTLV infection may have a role in some
patients in the pathogenesis of LGL leukemia.
Volume 80,
Issue 5,
pp. 1116-1119,
09/01/1992
Copyright © 1992 by The American Society of Hematology
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