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Interleukin-11 stimulates multiple phases of erythropoiesis in vitro
VF Quesniaux, SC Clark, K Turner and B Fagg
Preclinical Research, Sandoz Pharma Ltd, Basel, Switzerland.
Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a
primate bone marrow stromal cell line, has been shown to stimulate T-
cell-dependent B-cell maturation, megakaryopoiesis, and various stages of
myeloid differentiation, but to inhibit adipogenesis. Because stromal cells
are essential for the maintenance of early hematopoietic progenitor cells
in long-term culture, we investigated the effects of IL-11 on multipotent
and erythroid precursors from murine bone marrow in vitro in suspension and
semisolid cultures. Our results show that in the presence of IL-3 or c-kit
ligand (KL), IL-11 has profound stimulatory effects on primitive
multilineage hematopoietic progenitors, pre-CFC(multi), as well as on
precursors representing various stages of erythroid differentiation
observable in vitro, including CFC(multi), BFU-E, and CFU-E. In addition,
the combination of KL with IL-11 also stimulated highly proliferative
erythroid progenitors that yield remarkable macroscopic erythroblast
colonies in culture. These results indicate that IL-11 is likely to play a
pivotal role in early hematopoiesis and at multiple stages of
erythropoiesis.
Volume 80,
Issue 5,
pp. 1218-1223,
09/01/1992
Copyright © 1992 by The American Society of Hematology
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