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E Naparstek, Y Hardan, M Ben-Shahar, A Nagler, R Or, M Mumcuoglu, L Weiss, S Samuel and S Slavin
Department of Bone Marrow Transplantation, Hadassah University Hospital,
Jerusalem, Israel.
We studied an alternative method of using hematopoietic growth factors
(HGFs) to enhance hematopoietic recovery in patients undergoing bone marrow
transplantation (BMT), by short in vitro preincubation. Twenty consecutive
patients with leukemia received T-cell-depleted allografts using
Campath-1G. Two thirds of the marrow was infused on the scheduled day of
transplant and one third of the marrow following preincubation with
granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3
(IL-3) on day 4. Engraftment parameters and duration of hospitalization
were compared by actuarial analysis to those of 40 historical controls.
Patients receiving the incubated boost had significantly faster platelet
recovery (P = .017) and shorter hospitalization period (P = .001) when
compared with the control subjects. Platelet count reached greater than 25
x 10(9)/L on day 17 (median) in the study group and on day 23 in the
controls. The median duration of hospitalization was 20 and 36 days,
respectively. In the early posttransplantation follow-up, two of four
patients in the study group died as a result of graft rejection, while all
13 deaths in the control group resulted from complications associated with
marrow suppression. We suggest that pretransplant in vitro activation of
bone marrow cells with IL-3 and GM-CSF may prove to be an efficient method
for enhancing marrow recovery after BMT.
This article has been cited by other articles:
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| Copyright © 1992 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
