|
|
 Previous Article | Table of Contents | Next Article 
Hematopoietic cytokines inhibit apoptosis induced by transforming growth
factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells
J Lotem and L Sachs
Department of Molecular Genetics and Virology, Weizmann Institute of
Science, Rehovot, Israel.
Transforming growth factor-beta 1 (TGF-beta 1) induces cell death in
myeloid leukemia by apoptosis. In the M1 myeloid leukemia, this induction
of apoptosis was inhibited by granulocyte colony-stimulating factor (G-CSF)
or interleukin-6 (IL-6) and to a lesser extent by IL-1 alpha. IL-3 and stem
cell factor/mast cell growth factor (SCF) showed only a marginal effect,
and granulocyte-macrophage and macrophage CSFs (GM-CSF and M-CSF,
respectively) were inactive. The induction of apoptosis by TGF-beta 1 in a
different myeloid leukemia (7-M12) was inhibited by GM-CSF and IL-3 but not
by the other cytokines. In the absence of TGF-beta 1, both M1 and 7-M12
leukemic cells were independent of hematopoietic cytokines for cell
viability and growth. The cytotoxic compounds vincristine, vinblastine,
adriamycin, cytosine arabinoside, cycloheximide, and sodium azide, some of
which are used in cancer chemotherapy, induced cell death by apoptosis in
both leukemias. As with TGF-beta 1, apoptosis induced by these cytotoxic
compounds was inhibited by GM-CSF (7-M12 leukemia) and by G-CSF or IL-6 (M1
leukemia). Cyclosporine A decreased cell multiplication in M1 cells without
inducing apoptosis, and G-CSF and IL-6 inhibited the cytostatic effect of
cyclosporine A. It is suggested that the clinical use of cytokines to
correct therapy-associated myelosuppression should be carefully timed to
avoid protection of malignant cells from the cytotoxic action of the
therapeutic compounds.
Volume 80,
Issue 7,
pp. 1750-1757,
10/01/1992
Copyright © 1992 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. Weisberg, R. D. Wright, D. W. McMillin, C. Mitsiades, A. Ray, R. Barrett, S. Adamia, R. Stone, I. Galinsky, A. L. Kung, et al.
Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
Mol. Cancer Ther.,
May 1, 2008;
7(5):
1121 - 1129.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. R. Hodge, W. Xiao, B. Peng, J. C. Cherry, D. J. Munroe, and W. L. Farrar
Enforced Expression of Superoxide Dismutase 2/Manganese Superoxide Dismutase Disrupts Autocrine Interleukin-6 Stimulation in Human Multiple Myeloma Cells and Enhances Dexamethasone-Induced Apoptosis
Cancer Res.,
July 15, 2005;
65(14):
6255 - 6263.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. A. Oskeritzian, W. Zhao, A. L. Pozez, N. M. Cohen, M. Grimes, and L. B. Schwartz
Neutralizing Endogenous IL-6 Renders Mast Cells of the MCT Type from Lung, but Not the MCTC Type from Skin and Lung, Susceptible to Human Recombinant IL-4-Induced Apoptosis
J. Immunol.,
January 1, 2004;
172(1):
593 - 600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lotem, H. Gal, R. Kama, N. Amariglio, G. Rechavi, E. Domany, L. Sachs, and D. Givol
Inhibition of p53-induced apoptosis without affecting expression of p53-regulated genes
PNAS,
May 27, 2003;
100(11):
6718 - 6723.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Bosshart, D. Aldinucci, and V. Gattei
Interleukin-3 Receptors in Hodgkin's Disease
Am. J. Pathol.,
January 1, 2003;
162(1):
355 - 357.
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Sjoblom, M. Wikland, and S. A. Robertson
Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Acts Independently of the Beta Common Subunit of the GM-CSF Receptor to Prevent Inner Cell Mass Apoptosis in Human Embryos
Biol Reprod,
December 1, 2002;
67(6):
1817 - 1823.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kitaura, N. Nagata, Y. Fujimura, H. Hotokezaka, N. Yoshida, and K. Nakayama
Effect of IL-12 on TNF-{alpha}-Mediated Osteoclast Formation in Bone Marrow Cells: Apoptosis Mediated by Fas/Fas Ligand Interaction
J. Immunol.,
November 1, 2002;
169(9):
4732 - 4738.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Ye, J. Zhou, J. W. Landen, E. M. Bradbury, and H. C. Joshi
Sustained Activation of p34cdc2 Is Required for Noscapine-induced Apoptosis
J. Biol. Chem.,
December 7, 2001;
276(50):
46697 - 46700.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Laurent and J.-P. Jaffrezou
Signaling pathways activated by daunorubicin
Blood,
August 15, 2001;
98(4):
913 - 924.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. A. Wynn, K. Miyakawa, E. Miyata, G. Dranoff, M. Takeya, and K. Takahashi
Role of Granulocyte/Macrophage Colony-Stimulating Factor in Zymocel-Induced Hepatic Granuloma Formation
Am. J. Pathol.,
January 1, 2001;
158(1):
131 - 145.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. O. Fortunel, A. Hatzfeld, and J. A. Hatzfeld
Transforming growth factor-beta : pleiotropic role in the regulation of hematopoiesis
Blood,
September 15, 2000;
96(6):
2022 - 2036.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. M. Heidel, P. S. MacWilliams, W. M. Baird, W. M. Dashwood, J. T. M. Buters, F. J. Gonzalez, M. C. Larsen, C. J. Czuprynski, and C. R. Jefcoate
Cytochrome P4501B1 Mediates Induction of Bone Marrow Cytotoxicity and Preleukemia Cells in Mice Treated with 7,12-Dimethylbenz[a]anthracene
Cancer Res.,
July 1, 2000;
60(13):
3454 - 3460.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
P Batard, M. Monier, N Fortunel, K Ducos, P Sansilvestri-Morel, T Phan, A Hatzfeld, and J. Hatzfeld
TGF-(beta)1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation
J. Cell Sci.,
January 2, 2000;
113(3):
383 - 390.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. M. Heidel, K. Holston, J. T.M. Buters, F. J. Gonzalez, C. R. Jefcoate, and C. J. Czupyrynski
Bone Marrow Stromal Cell Cytochrome P4501B1 Is Required for Pre-B Cell Apoptosis Induced by 7,12-Dimethylbenz[a]anthracene
Mol. Pharmacol.,
December 1, 1999;
56(6):
1317 - 1323.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C. A. Oskeritzian, Z. Wang, J. P. Kochan, M. Grimes, Z. Du, H.-W. Chang, S. Grant, and L. B. Schwartz
Recombinant Human (rh)IL-4-Mediated Apoptosis and Recombinant Human IL-6-Mediated Protection of Recombinant Human Stem Cell Factor-Dependent Human Mast Cells Derived from Cord Blood Mononuclear Cell Progenitors
J. Immunol.,
November 1, 1999;
163(9):
5105 - 5115.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G. Wickremasinghe and A. V. Hoffbrand
Biochemical and Genetic Control of Apoptosis: Relevance to Normal Hematopoiesis and Hematological Malignancies
Blood,
June 1, 1999;
93(11):
3587 - 3600.
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Y. Chin, I. Petrache, A. M. K. Choi, and M. E. Choi
Transforming Growth Factor beta 1 Rescues Serum Deprivation-induced Apoptosis via the Mitogen-activated Protein Kinase (MAPK) Pathway in Macrophages
J. Biol. Chem.,
April 16, 1999;
274(16):
11362 - 11368.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. O. Armitage
Emerging Applications of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor
Blood,
December 15, 1998;
92(12):
4491 - 4508.
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Lizard, S. Gueldry, O. Sordet, S. Monier, A. Athias, C. Miguet, G. Bessede, S. Lemaire, E. Solary, and P. Gambert
Glutathione is implied in the control of 7-ketocholesterol-induced apoptosis, which is associated with radical oxygen species production
FASEB J,
December 1, 1998;
12(15):
1651 - 1663.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
C.-S. Chung, Y. X. Xu, W. Wang, I. H. Chaudry, and A. Ayala
Is Fas Ligand or Endotoxin Responsible for Mucosal Lymphocyte Apoptosis in Sepsis?
Arch Surg,
November 1, 1998;
133(11):
1213 - 1220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Selleri, J. P. Maciejewski, F. Pane, L. Luciano, A. M. Raiola, I. Mostarda, F. Salvatore, and B. Rotoli
Fas-Mediated Modulation of Bcr/Abl in Chronic Myelogenous Leukemia Results in Differential Effects on Apoptosis
Blood,
August 1, 1998;
92(3):
981 - 989.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. S. Haneline, H. E. Broxmeyer, S. Cooper, G. Hangoc, M. Carreau, M. Buchwald, and D. W. Clapp
Multiple Inhibitory Cytokines Induce Deregulated Progenitor Growth and Apoptosis in Hematopoietic Cells From Fac-/- Mice
Blood,
June 1, 1998;
91(11):
4092 - 4098.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lotem and L. Sachs
Different mechanisms for suppression of apoptosis by cytokines and calcium mobilizing compounds
PNAS,
April 14, 1998;
95(8):
4601 - 4606.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Dubrez, B. Eymin, O. Sordet, N. Droin, A. G. Turhan, and E. Solary
BCR-ABL Delays Apoptosis Upstream of Procaspase-3 Activation
Blood,
April 1, 1998;
91(7):
2415 - 2422.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Dybedal, F. Guan, O. J. Borge, O. P. Veiby, V. Ramsfjell, S. Nagata, and S. E. W. Jacobsen
Transforming Growth Factor-beta 1 Abrogates Fas-Induced Growth Suppression and Apoptosis of Murine Bone Marrow Progenitor Cells
Blood,
November 1, 1997;
90(9):
3395 - 3403.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. J. Borge, V. Ramsfjell, L. Cui, and S. E.W. Jacobsen
Ability of Early Acting Cytokines to Directly Promote Survival and Suppress Apoptosis of Human Primitive CD34+CD38- Bone Marrow Cells With Multilineage Potential at the Single-Cell Level: Key Role of Thrombopoietin
Blood,
September 15, 1997;
90(6):
2282 - 2292.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Lotem and L. Sachs
Cytokine suppression of protease activation in wild-type p53-dependent and p53-independent apoptosis
PNAS,
August 19, 1997;
94(17):
9349 - 9353.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Saeki, A. Yuo, M. Kato, K. Miyazono, Y. Yazaki, and F. Takaku
Cell Density-dependent Apoptosis in HL-60 Cells, Which Is Mediated by an Unknown Soluble Factor, Is Inhibited By Transforming Growth Factor beta 1 and Overexpression of Bcl-2
J. Biol. Chem.,
August 8, 1997;
272(32):
20003 - 20010.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. C. Han, M. Lu, J. Li, M. Defard, B. Boval, N. Schlegel, and J. P. Caen
Platelet Factor 4 and Other CXC Chemokines Support the Survival of Normal Hematopoietic Cells and Reduce the Chemosensitivity of Cells to Cytotoxic Agents
Blood,
April 1, 1997;
89(7):
2328 - 2335.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. A. Hannun
Apoptosis and the Dilemma of Cancer Chemotherapy
Blood,
March 15, 1997;
89(6):
1845 - 1853.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. de Luca, M. Weller, and A. Fontana
TGF-beta -Induced Apoptosis of Cerebellar Granule Neurons Is Prevented by Depolarization
J. Neurosci.,
July 1, 1996;
16(13):
4174 - 4185.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. F. Sachsenmeier, N. Sheibani, S. J. Schlosser, and B. L. Allen-Hoffmann
Transforming Growth Factor-beta1 Inhibits Nucleosomal Fragmentation in Human Keratinocytes following Loss of Adhesion
J. Biol. Chem.,
January 5, 1996;
271(1):
5 - 8.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Palumbo and J. Yeh
Apoptosis as a Basic Mechanism in the Ovarian Cycle: Folicular Atresia and Luteal Regression
Reproductive Sciences,
May 1, 1995;
2(3):
565 - 573.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. M. Francis, C. M. Heyworth, E. Spooncer, A. Pierce, T. M. Dexter, and A. D. Whetton
Transforming Growth Factor-beta 1 Induces Apoptosis Independently of p53 and Selectively Reduces Expression of Bcl-2 in Multipotent Hematopoietic Cells
J. Biol. Chem.,
December 8, 2000;
275(50):
39137 - 39145.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
