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FVT-1, a novel human transcription unit affected by variant translocation
t(2;18)(p11;q21) of follicular lymphoma
R Rimokh, M Gadoux, MF Bertheas, F Berger, M Garoscio, G Deleage, D Germain and JP Magaud
Equipe de Cytologie Analytique et de Cytogenetique Moleculaire, Hopital
Edouard Herriot, Lyon, France.
Variant t(2;18) and t(18;22) chromosome translocations observed in B- cell
chronic lymphocytic leukemias and in follicular lymphomas have been
reported to consistently involve the 5' region of the BCL-2 gene on
chromosome 18 and various regions on the lg light chain loci. We show here
that a variant t(2;18)(p11;q21) translocation observed in a case of
follicular lymphoma leads to the juxtaposition of a J kappa segment to a
chromosome 18 transcriptional unit located 10 kpb upstream of the BCL-2
locus. The cDNA of this new evolutionarily conserved gene, termed FVT-1 for
follicular-variant-translocation gene, codes for a putatively secreted
protein of 36 Kd that is not homologous with any described protein. The
FVT-1 gene is weakly expressed in all the analyzed normal hematopoietic
tissues but a very high rate of transcription is observed in some T-cell
malignancies and in phytohemagglutinin-stimulated lymphocytes. The
proximity of FVT-1 to the BCL-2 locus suggests that in the t(14;18)
currently observed in follicular lymphomas, both genes would participate in
the tumoral process.
Volume 81,
Issue 1,
pp. 136-142,
01/01/1993
Copyright © 1993 by The American Society of Hematology
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