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Effects of recombinant human interleukin-11 on hematopoietic reconstitution
in transplant mice: acceleration of recovery of peripheral blood
neutrophils and platelets
XX Du, T Neben, S Goldman and DA Williams
Herman B Wells Center for Pediatric Research, James Whitcomb Riley Hospital
for Children, Indiana University School of Medicine, Indianapolis
46202-5225.
We have examined the effects of recombinant human interleukin-11 (rhIL- 11)
on the recovery of peripheral blood cell counts and proliferation of
progenitors and hematopoietic stem cells (day 12 colony-forming
units-spleen-CFU-S12) in vivo using a mouse bone marrow (BM) and spleen
cell transplantation model. Recovery of leukocytes was accelerated in
animals receiving daily administration of rhIL-11 (100 micrograms/kg/d) and
reached normal levels by day 14 posttransplantation. This increased total
leukocyte count reflected mainly an increase in neutrophils. Neutropenia
(absolute neutrophil count [ANC] < 1,500) was present in control
transplant mice for 14 to 15 days, while in the rhIL-11-treated group,
neutrophils recovered to normal by days 8 to 10 and continued to increase
until day 19. Animals treated with rhIL-11 had only 1 day with ANC
demonstrated < 500. Correspondingly, rhIL-11 treatment increased
granulocyte-macrophage progenitors (CFU-GM) derived from both spleen and BM
cells. Higher doses of IL-11 increased CFU-GM nearly threefold and CFU-Mix
fourfold to fivefold, while increasing burst-forming units- erythroid to a
lesser degree. BM and spleen cellularity were both increased in
IL-11-treated mice, but no increase in CFU-S12 was noted. In addition, in
vivo daily administration of IL-11 increased peripheral platelet counts by
threefold over control transplant mice at day 10 posttransplantation during
the post-irradiation platelet nadir. Further treatment led to platelet
counts higher than normal 18 days posttransplantation when control animals
had just attained normal platelet counts. IL-11 can accelerate the recovery
of the peripheral blood leukocytes, mainly neutrophils, and platelets in
transplant mice, effects that may be clinically useful in future
applications for BM transplantation and chemotherapy-related cytopenias.
Volume 81,
Issue 1,
pp. 27-34,
01/01/1993
Copyright © 1993 by The American Society of Hematology
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