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Human platelets secrete chemotactic activity for eosinophils
JA Burgers, RC Schweizer, L Koenderman, PL Bruijnzeel and JW Akkerman
Department of Hematology, University Hospital Utrecht, The Netherlands.
Thrombin-stimulated platelets liberate factors that induce chemotaxis of
eosinophils and raise their cytosolic Ca2+ content ([Ca2+]i). The sources
of this activity are the dense- and alpha-granules because inhibition of
prostaglandin endoperoxide/thromboxane A2 formation and the
platelet-activating factor receptor-antagonist WEB 2086 have no effect.
Platelets from patients with Storage-Pool Deficiency show about 60% of the
normal chemotactic activity with little effect on [Ca2+]i, whereas
completely degranulated platelets fail to affect eosinophils. In
concentrations secreted by the platelets, adenosine diphosphate (ADP), and
platelet factor 4 have no effect, whereas adenosine triphosphate (ATP)
induces a strong chemotactic response and increases [Ca2+]i. However, apart
from ATP other modulating factors must be involved as platelet releasates
induce more chemotaxis than ATP alone. Thus, platelets secrete factors that
activate eosinophils and may contribute to inflammatory and allergic
processes.
Volume 81,
Issue 1,
pp. 49-55,
01/01/1993
Copyright © 1993 by The American Society of Hematology
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