|
|
 Previous Article | Table of Contents | Next Article 
Activated platelets induce endothelial secretion of interleukin-8 in vitro
via an interleukin-1-mediated event
G Kaplanski, R Porat, K Aiura, JK Erban, JA Gelfand and CA Dinarello
Department of Medicine, New England Medical Center Hospitals, Boston, MA
02111.
Migration of neutrophils through endothelial cells (EC) and induction of
cytokine secretion are two well-documented events during the inflammatory
reaction. The inflammatory, chemotactic cytokine interleukin-8 (IL-8) is
secreted by EC in response to IL-1 stimulation. In this study, we show that
platelets activated with either adenosine- 5'-diphosphate or epinephrine
induce IL-8 secretion by EC. This stimulatory activity was found to be
associated with sedimented platelets after activation. Blockade of IL-1
receptors on EC with IL-1 receptor antagonist (IL-1Ra) decreased the
stimulatory effect of whole activated platelet preparations by 59% (P <
.05). Similarly, IL-1Ra pretreatment of EC reduced the stimulatory effect
of sedimented activated platelets by 60% (P < .01). In addition, we
treated human blood donors with 750 mg of oral aspirin, and evaluated the
stimulatory effect of epinephrine-activated platelets on IL-8 secretion by
EC. IL-8 synthesis after aspirin ingestion was inhibited by 90% (P <
.01) as compared with the preaspirin stimulation. These observations show
that activated platelets induce IL-8 secretion via membrane-associated IL-1
activity, and provide a novel relationship between coagulation and
inflammation that could be relevant to several diseases.
Volume 81,
Issue 10,
pp. 2492-2495,
05/15/1993
Copyright © 1993 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
G. A. Zimmerman and A. S. Weyrich
Signal-Dependent Protein Synthesis by Activated Platelets: New Pathways to Altered Phenotype and Function
Arterioscler Thromb Vasc Biol,
March 1, 2008;
28(3):
s17 - s24.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. von Hundelshausen and C. Weber
Platelets as Immune Cells: Bridging Inflammation and Cardiovascular Disease
Circ. Res.,
January 5, 2007;
100(1):
27 - 40.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Saadi, T. Takahashi, R. A. Holzknecht, and J. L. Platt
Pathways to Acute Humoral Rejection
Am. J. Pathol.,
March 1, 2004;
164(3):
1073 - 1080.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. McRedmond, S. D. Park, D. F. Reilly, J. A. Coppinger, P. B. Maguire, D. C. Shields, and D. J. Fitzgerald
Integration of Proteomics and Genomics in Platelets: A PROFILE OF PLATELET PROTEINS AND PLATELET-SPECIFIC GENES
Mol. Cell. Proteomics,
February 1, 2004;
3(2):
133 - 144.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Niki, H. Yamada, T. Kikuchi, Y. Toyama, H. Matsumoto, K. Fujikawa, and N. Tada
Membrane-Associated IL-1 Contributes to Chronic Synovitis and Cartilage Destruction in Human IL-1{alpha} Transgenic Mice
J. Immunol.,
January 1, 2004;
172(1):
577 - 584.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. OSTERUD and E. BJORKLID
Role of Monocytes in Atherogenesis
Physiol Rev,
October 1, 2003;
83(4):
1069 - 1112.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Garcia-Ramallo, T. Marques, N. Prats, J. Beleta, S. L. Kunkel, and N. Godessart
Resident Cell Chemokine Expression Serves as the Major Mechanism for Leukocyte Recruitment During Local Inflammation
J. Immunol.,
December 1, 2002;
169(11):
6467 - 6473.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. G. Christen, R. J. Glynn, U. A. Ajani, D. A. Schaumberg, E. Y. Chew, J. E. Buring, J. E. Manson, and C. H. Hennekens
Age-Related Maculopathy in a Randomized Trial of Low-Dose Aspirin Among US Physicians
Arch Ophthalmol,
August 1, 2001;
119(8):
1143 - 1149.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. J. Elenkov, R. L. Wilder, G. P. Chrousos, and E. S. Vizi
The Sympathetic Nerve---An Integrative Interface between Two Supersystems: The Brain and the Immune System
Pharmacol. Rev.,
December 1, 2000;
52(4):
595 - 638.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Massberg, G. Enders, F. C. d. M. Matos, L. I. D. Tomic, R. Leiderer, S. Eisenmenger, K. Messmer, and F. Krombach
Fibrinogen Deposition at the Postischemic Vessel Wall Promotes Platelet Adhesion During Ischemia-Reperfusion In Vivo
Blood,
December 1, 1999;
94(11):
3829 - 3838.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. A. Schwarz, R. S. Amin, J. M. Stark, B. C. Trapnell, and R. W. Wilmott
Interleukin-1 Receptor Antagonist Inhibits Interleukin-8 Expression in A549 Respiratory Epithelial Cells Infected In Vitro with a Replication-Deficient Recombinant Adenovirus Vector
Am. J. Respir. Cell Mol. Biol.,
September 1, 1999;
21(3):
388 - 394.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
L. M. Biasucci, G. Liuzzo, G. Fantuzzi, G. Caligiuri, A. G. Rebuzzi, F. Ginnetti, C. A. Dinarello, and A. Maseri
Increasing Levels of Interleukin (IL)-1Ra and IL-6 During the First 2 Days of Hospitalization in Unstable Angina Are Associated With Increased Risk of In-Hospital Coronary Events
Circulation,
April 27, 1999;
99(16):
2079 - 2084.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Rothe, P. Collin-Osdoby, Y. Chen, T. Sunyer, L. Chaudhary, A. Tsay, S. Goldring, L. Avioli, and P. Osdoby
Human Osteoclasts and Osteoclast-Like Cells Synthesize and Release High Basal and Inflammatory Stimulated Levels of the Potent Chemokine Interleukin-8
Endocrinology,
October 1, 1998;
139(10):
4353 - 4363.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Kaplanski, V. Marin, M. Fabrigoule, V. Boulay, A.-M. Benoliel, P. Bongrand, S. Kaplanski, and C. Farnarier
Thrombin-Activated Human Endothelial Cells Support Monocyte Adhesion In Vitro Following Expression of Intercellular Adhesion Molecule-1 (ICAM-1; CD54) and Vascular Cell Adhesion Molecule-1 (VCAM-1; CD106)
Blood,
August 15, 1998;
92(4):
1259 - 1267.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Loppnow, R. Bil, S. Hirt, U. Schonbeck, M. Herzberg, K. Werdan, E. Theodor Rietschel, E. Brandt, and H.-D. Flad
Platelet-Derived Interleukin-1 Induces Cytokine Production, but not Proliferation of Human Vascular Smooth Muscle Cells
Blood,
January 1, 1998;
91(1):
134 - 141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
