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Drosophila forkhead homologues are expressed in a lineage-restricted manner
in human hematopoietic cells
R Hromas, J Moore, T Johnston, C Socha and M Klemsz
Department of Hematology/Oncology, Indiana University Medical Center,
Indianapolis 46202-5121.
The forkhead gene (FKH) regulates morphogenesis in Drosophila. It is the
prototype of a new family of transcriptional activators. Partially
degenerate oligonucleotides to two conserved amino acid sequences of this
family were used to prime a polymerase chain reaction (PCR) amplification
of HEL cell cDNA. Two unique clones, designated H3 and H8, were isolated
that contained homologies to FKH. A third novel clone, 5-3, was isolated by
low stringency screening of a chronic myelogenous leukemia cDNA library
using H8 as a probe. H3 and 5-3 are preferentially expressed in restricted
hematopoietic lineages, while the expression of H8 was ubiquitous. Southern
analysis showed that FKH 5-3 is conserved through yeast, which is rare
among tissue-specific transcription factors. The H3 and 5-3 clones provide
evidence that FKH family members are present in a tissue-restricted manner
in humans.
Volume 81,
Issue 11,
pp. 2854-2859,
06/01/1993
Copyright © 1993 by The American Society of Hematology
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