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Hematopoietic growth factor receptor genes as markers of lineage commitment
during in vitro development of hematopoietic cells [see comments]
T McClanahan, S Dalrymple, M Barkett and F Lee
DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA
94304-1104.
We have used two in vitro models to identify genes whose expression may
serve as markers of lineage commitment during the development of
hematopoietic stem cells. One system involves the development in vitro of
blastocyst-derived embryonic stem cells into embryoid bodies. The second
involves culturing of day 3.5 blastocysts in vitro under conditions that
support their development into yolk saclike cysts. In both cases,
hematopoietic cells arise in a manner that closely mimics the normal
process occurring in the yolk sac of the early mouse embryo. We have
focused our analysis on the expression of mRNAs for 15 hematopoietic growth
factor receptor genes and other genes expressed in a hematopoietic
lineage-specific manner. Although some growth factor receptor genes are
apparently expressed constitutively during in vitro development, there are
several classes of genes that undergo a highly consistent pattern of
induction in both model systems. Genes induced early include those encoding
the shared beta subunits of the interleukin-3 (IL-3), IL-5, and
granulocyte-macrophage colony- stimulating factor (GM-CSF) receptors; those
induced at intermediate times include the c-fms, G-CSF receptor, and CD34
genes; and a gene induced late during in vitro development is the IL-7
receptor gene. The defined temporal order for the expression of these genes
suggests that they may be useful as markers for multiple stages in the
development of different hematopoietic cell lineages during embryogenesis.
Volume 81,
Issue 11,
pp. 2903-2915,
06/01/1993
Copyright © 1993 by The American Society of Hematology
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