|
|
 Previous Article | Table of Contents | Next Article 
Erythropoietin induces tyrosine phosphorylation and kinase activity of the
c-fps/fes proto-oncogene product in human erythropoietin-responsive cells
Y Hanazono, S Chiba, K Sasaki, H Mano, Y Yazaki and H Hirai
Third Department of Internal Medicine, Faculty of Medicine, University of
Tokyo, Japan.
Erythropoietin (EPO) is a hematopoietic growth factor that stimulates the
proliferation and differentiation of erythroid progenitor cells. Although
the EPO receptor has no kinase domain, EPO rapidly induces tyrosine
phosphorylation of several proteins in EPO-responsive cells. Therefore, the
receptor activation by the ligand could induce tyrosine- kinase activity of
unidentified cellular protein(s). Here we show that c-fps/fes
proto-oncogene product (p92c-fes), nonreceptor tyrosine kinase, is
tyrosine-phosphorylated on treatment with EPO in a human erythroleukemia
cell line TF-1 that is responsive to granulocyte- macrophage
colony-stimulating factor, interleukin-3, and EPO. In addition, the kinase
activity of p92c-fes was shown to be enhanced by treatment with EPO.
Therefore, p92c-fes could be implicated in a signaling pathway triggered by
EPO in human EPO-responsive cells.
Volume 81,
Issue 12,
pp. 3193-3196,
06/15/1993
Copyright © 1993 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. J. Haigh, M. Ema, K. Haigh, M. Gertsenstein, P. Greer, J. Rossant, A. Nagy, and E. F. Wagner
Activated Fps/Fes partially rescues the in vivo developmental potential of Flk1-deficient vascular progenitor cells
Blood,
February 1, 2004;
103(3):
912 - 920.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D.-M. McCafferty, A. W. B. Craig, Y. A. Senis, and P. A. Greer
Absence of Fer Protein-Tyrosine Kinase Exacerbates Leukocyte Recruitment in Response to Endotoxin
J. Immunol.,
May 15, 2002;
168(10):
4930 - 4935.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Zirngibl, Y. Senis, and P. A. Greer
Enhanced Endotoxin Sensitivity in Fps/Fes-Null Mice with Minimal Defects in Hematopoietic Homeostasis
Mol. Cell. Biol.,
April 15, 2002;
22(8):
2472 - 2486.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kirito, K. Nakajima, T. Watanabe, M. Uchida, M. Tanaka, K. Ozawa, and N. Komatsu
Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation
Blood,
January 1, 2002;
99(1):
102 - 110.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Jiang, K. Foltenyi, M. Kashiwada, L. Donahue, B. Vuong, B. Hehn, and P. Rothman
Fes Mediates the IL-4 Activation of Insulin Receptor Substrate-2 and Cellular Proliferation
J. Immunol.,
February 15, 2001;
166(4):
2627 - 2634.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. W. B. Craig, R. Zirngibl, K. Williams, L.-A. Cole, and P. A. Greer
Mice Devoid of Fer Protein-Tyrosine Kinase Activity Are Viable and Fertile but Display Reduced Cortactin Phosphorylation
Mol. Cell. Biol.,
January 15, 2001;
21(2):
603 - 613.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. A. Rogers, H. Y. Cheng, and T. E. Smithgall
Src Homology 2 Domain Substitution Modulates the Kinase and Transforming Activities of the Fes Protein-Tyrosine Kinase
Cell Growth Differ.,
November 1, 2000;
11(11):
581 - 592.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K. Nishigaki, C. Hanson, T. Ohashi, D. Thompson, K. Muszynski, and S. Ruscetti
Erythroid Cells Rendered Erythropoietin Independent by Infection with Friend Spleen Focus-Forming Virus Show Constitutive Activation of Phosphatidylinositol 3-Kinase and Akt Kinase: Involvement of Insulin Receptor Substrate-Related Adapter Proteins
J. Virol.,
April 1, 2000;
74(7):
3037 - 3045.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
J. M. Lionberger and T. E. Smithgall
The c-Fes Protein-Tyrosine Kinase Suppresses Cytokine-independent Outgrowth of Myeloid Leukemia Cells Induced by Bcr-Abl
Cancer Res.,
February 1, 2000;
60(4):
1097 - 1103.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
H. Cheng, J. A. Rogers, N. A. Dunham, and T. E. Smithgall
Regulation of c-Fes Tyrosine Kinase and Biological Activities by N-Terminal Coiled-Coil Oligomerization Domains
Mol. Cell. Biol.,
December 1, 1999;
19(12):
8335 - 8343.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Senis, R. Zirngibl, J. McVeigh, A. Haman, T. Hoang, and P. A. Greer
Targeted Disruption of the Murine fps/fes Proto-Oncogene Reveals that Fps/Fes Kinase Activity Is Dispensable for Hematopoiesis
Mol. Cell. Biol.,
November 1, 1999;
19(11):
7436 - 7446.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Miller, D. L. Barber, L. L. Bell, B. K. Beattie, M.-Y. Zhang, B. G. Neel, M. Yoakim, L. I. Rothblum, and J. Y. Cheung
Identification of the Erythropoietin Receptor Domain Required for Calcium Channel Activation
J. Biol. Chem.,
July 16, 1999;
274(29):
20465 - 20472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Bao, S. M. Jacobs-Helber, A. E. Lawson, K. Penta, A. Wickrema, and S. T. Sawyer
Protein Kinase B (c-Akt), Phosphatidylinositol 3-Kinase, and STAT5 Are Activated by Erythropoietin (EPO) in HCD57 Erythroid Cells But Are Constitutively Active in an EPO-Independent, Apoptosis-Resistant Subclone (HCD57-SREI Cells)
Blood,
June 1, 1999;
93(11):
3757 - 3773.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.A. Cole, R. Zirngibl, A.W.B. Craig, Z. Jia, and P. Greer
Mutation of a highly conserved aspartate residue in subdomain IX abolishes Fer protein-tyrosine kinase activity
Protein Eng. Des. Sel.,
February 1, 1999;
12(2):
155 - 162.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. LOSMAN, X.P. CHEN, H. JIANG, P.-Y. PAN, M. KASHIWADA, C. GIALLOURAKIS, S. COWAN, K. FOLTENYI, and P. ROTHMAN
IL-4 Signaling Is Regulated through the Recruitment of Phosphatases, Kinases, and SOCS Proteins to the Receptor Complex
Cold Spring Harb Symp Quant Biol,
January 1, 1999;
64(0):
405 - 416.
[Abstract]
[PDF]
|
|
|
|
|
|
|
V. Duprez, U. Blank, S. Chretien, S. Gisselbrecht, and P. Mayeux
Physical and Functional Interaction between p72syk and Erythropoietin Receptor
J. Biol. Chem.,
December 18, 1998;
273(51):
33985 - 33990.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Li and T. E. Smithgall
Fibroblast Transformation by Fps/Fes Tyrosine Kinases Requires Ras, Rac, and Cdc42 and Induces Extracellular Signal-regulated and c-Jun N-terminal Kinase Activation
J. Biol. Chem.,
May 29, 1998;
273(22):
13828 - 13834.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. L. Nelson, J. A. Rogers, T. L. Bowman, R. Jove, and T. E. Smithgall
Activation of STAT3 by the c-Fes Protein-tyrosine Kinase
J. Biol. Chem.,
March 20, 1998;
273(12):
7072 - 7077.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. Smithgall
Signal Transduction Pathways Regulating Hematopoietic Differentiation
Pharmacol. Rev.,
March 1, 1998;
50(1):
1 - 20.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Read, J. M. Lionberger, and T. E. Smithgall
Oligomerization of the Fes Tyrosine Kinase. EVIDENCE FOR A COILED-COIL DOMAIN IN THE UNIQUE N-TERMINAL REGION
J. Biol. Chem.,
July 18, 1997;
272(29):
18498 - 18503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Rogers, R. D. Read, J. Li, K. L. Peters, and T. E. Smithgall
Autophosphorylation of the Fes Tyrosine Kinase. EVIDENCE FOR AN INTERMOLECULAR MECHANISM INVOLVING TWO KINASE DOMAIN TYROSINE RESIDUES
J. Biol. Chem.,
July 19, 1996;
271(29):
17519 - 17525.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. A. Tilbrook, T. Bittorf, S. J. Busfield, D. Chappell, and S. P. Klinken
Disrupted Signaling in a Mutant J2E Cell Line That Shows Enhanced Viability, but Does Not Proliferate or Differentiate, with Erythropoietin
J. Biol. Chem.,
February 16, 1996;
271(7):
3453 - 3459.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Odai, K. Sasaki, A. Iwamatsu, Y. Hanazono, T. Tanaka, K. Mitani, Y. Yazaki, and H. Hirai
The Proto-oncogene Product c-Cbl Becomes Tyrosine Phosphorylated by Stimulation with GM-CSF or Epo and Constitutively Binds to the SH3 Domain of Grb2/Ash in Human Hematopoietic Cells
J. Biol. Chem.,
May 5, 1995;
270(18):
10800 - 10805.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T Taniguchi
Cytokine signaling through nonreceptor protein tyrosine kinases
Science,
April 14, 1995;
268(5208):
251 - 255.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. Linnekin, S. M. Mou, P. Greer, D. L. Longo, and D. K. Ferris
Phosphorylation of a Fes-related Protein in Response to Granulocyte-Macrophage Colony Stimulating Factor
J. Biol. Chem.,
March 3, 1995;
270(9):
4950 - 4954.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Guillard, S. Chretien, R. Jockers, S. Fichelson, P. Mayeux, and V. Duprez
Coupling of Heterotrimeric Gi Proteins to the Erythropoietin Receptor
J. Biol. Chem.,
January 12, 2001;
276(3):
2007 - 2014.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
