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Recombinant human leukemia inhibitory factor induces acute phase proteins
and raises the blood platelet counts in nonhuman primates
P Mayer, K Geissler, M Ward and D Metcalf
Sandoz Research Institute, Vienna, Austria.
Recombinant human leukemia inhibitory factor (rhLIF) produced by
Escherichia coli was administered subcutaneously (sc) to rhesus monkeys at
doses of 2, 10, and 50 micrograms/kg body weight/d for 14 days to assess
its biologic activities in vivo. Serum levels of positively regulated acute
phase proteins (APP) (C-reactive protein, alpha 1- antitrypsin,
haptoglobin, and ceruloplasmin) were increased, whereas the negatively
regulated APP prealbumin decreased in response to rhLIF treatment. During
the second week of treatment, blood platelet counts began to increase,
resulting in a maximum of a twofold increase above normal levels a week
after termination of the rhLIF treatment. No changes were seen in total and
differential white blood cell counts in blood progenitor levels and in red
blood cell numbers. The low- and medium-dose rhLIF treatments were
tolerated without significant side effects. The animals treated with the
high dose showed a reduction in body weight of approximately 10%. In
conclusion, rhLIF was shown to stimulate APP and to increase the number of
platelets in circulation in nonhuman primates.
Volume 81,
Issue 12,
pp. 3226-3233,
06/15/1993
Copyright © 1993 by The American Society of Hematology
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