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Levels of soluble stem cell factor in serum of patients with aplastic
anemia
A Wodnar-Filipowicz, S Yancik, Y Moser, V dalle Carbonare, A Gratwohl, A Tichelli, B Speck and C Nissen
Department of Research, University Hospital, Basel, Switzerland.
Aplastic anemia (AA) is a rare bone marrow (BM) disorder characterized by
an unexplained failure of hematopoietic precursors to proliferate. In vitro
growth of AA BM cells can be improved by the addition of the hematopoietic
growth factor SCF (stem cell factor), which suggests that deficiency of SCF
may be one of the underlying causes of the disease. In this study, we
measured the concentration of SCF in sera of patients with severe AA. One
hundred twenty-eight serum samples from 32 patients, at diagnosis and
following therapy, were analyzed. Before treatment, SCF levels varied
between 0.33 and 6.1 ng/mL; no correlation between hematopoietic function
and SCF serum levels was apparent. Therapy with antilymphocyte globulin
(ALG) or bone marrow transplantation (BMT) did not result in a recognizable
pattern of changes in SCF levels. However, serum concentration of SCF in
many patients with AA was at the low range of control serum levels
determined in healthy blood donors. Of 128 AA serum samples tested before
and after therapy, 107 were below the mean normal value of 3.3 ng/mL,
including 26 samples below the minimum normal value of 1.3 ng/mL, as
estimated in 267 controls. We also found that SCF levels in peripheral
blood serum correlate well with factor concentrations in the BM plasma.
Clinical observations suggest that higher SCF serum levels are often
associated with a better clinical status of the patients in terms of
survival and transfusion requirements. The data indicate that a deficient
production of soluble SCF may contribute to AA in some patients; thus,
suggesting a potential therapeutic benefit of SCF in this disorder.
Volume 81,
Issue 12,
pp. 3259-3264,
06/15/1993
Copyright © 1993 by The American Society of Hematology
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