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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by McFarland, J. G. Articles by Aster, R. H. Search for Related Content PubMed PubMed Citation Articles by McFarland, J. G. Articles by Aster, R. H. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Neonatal alloimmune thrombocytopenia due to a new platelet-specific alloantibody JG McFarland, V Blanchette, J Collins, PJ Newman, R Wang and RH Aster Blood Center of Southeastern Wisconsin, Milwaukee 53233. An infant with severe neonatal alloimmune thrombocytopenia is described in whom an antibody directed at a new platelet-specific alloantigen, Ca (HPA-6b), is implicated. The new alloantigen is of low frequency in the population and was localized to platelet glycoprotein (GP) IIIa. Immunoprecipitation studies using murine monoclonal antibodies specific for the GP complex IIb-IIIa and GPIIIa alone (AP2 and AP3) suggest that the location of the Ca epitope on GPIIIa may be near the binding site for AP3. Neonatal alloimmune thrombocytopenia associated with Ca is likely to be as severe as that seen in cases due to incompatibilities for the HPA-1 (PIA) and HPA-4 (Pen) platelet alloantigen systems, because each is located on GPIIIa, a densely represented molecule on the platelet surface. Volume 81, Issue 12, pp. 3318-3323, 06/15/1993 Copyright © 1993 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

	Copyright © 1993 by American Society of Hematology         Online ISSN: 1528-0020