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Epstein-Barr virus and childhood Hodgkin's disease in Honduras and the
United States
RF Ambinder, PJ Browning, I Lorenzana, BG Leventhal, H Cosenza, RB Mann, EM MacMahon, R Medina, V Cardona and S Grufferman
Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD.
In industrialized populations, Hodgkin's disease (HD) has an initial peak
in young adulthood, whereas in economically developing populations the
initial peak occurs in childhood. This pattern resembles that of infection
with poliovirus and suggests an infectious cofactor in the etiology.
Serologic studies have linked Epstein-Barr virus (EBV) to young adult and
adult HD, and viral nucleic acids and antigens have been detected in a
subset of Hodgkin's tumor specimens. To investigate the association of
childhood HD with EBV we studied tumor specimens from 11 children treated
in Honduras and 25 children treated in the United States using in situ
hybridization and antigen detection techniques. Among the patients from
Honduras, tumor specimens from all cases were EBV positive. Among the
patients from the United States, tumor specimens from six of seven patients
with mixed cellularity histology, 2 of 15 with nodular sclerosis histology,
and neither of two patients with lymphocyte-predominant histologies were
EBV positive. These findings support the hypothesis that EBV contributes to
the pathogenesis of HD in children, particularly in mixed cellularity HD,
and raises the possibility that there are important geographic, racial, or
ethnic factors in the EBV association with HD.
Volume 81,
Issue 2,
pp. 462-467,
01/15/1993
Copyright © 1993 by The American Society of Hematology
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