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High prevalence of Epstein-Barr virus in the Reed-Sternberg cells of
Hodgkin's disease occurring in Peru
KL Chang, PF Albujar, YY Chen, RM Johnson and LM Weiss
Division of Pathology, City of Hope National Medical Center, Duarte, CA
91010.
The Epstein-Barr virus (EBV) has been implicated in the pathogenesis of
Hodgkin's disease (HD). This study was undertaken to determine whether the
association of EBV with HD showed geographical variation, as in Burkitt's
lymphoma. We studied 32 formalin-fixed, paraffin-embedded cases of HD
occurring in Peru. EBV DNA-RNA in situ hybridization was performed using a
30-base biotinylated antisense oligonucleotide complementary to the EBER1
gene of EBV. EBV immunohistochemistry was also performed, using a
monoclonal antibody (MoAb) to the latent membrane protein (LMP1) of EBV.
Identification of the precise cellular subset staining with EBV was
accomplished via double-labeling with MoAbs directed against Reed-Sternberg
cells (LeuM1/CD15) and B cells (L26/CD20). EBV RNA was identified in all or
virtually all of the Reed- Sternberg cells and variants in 30 of the 32
(94%) cases of HD by in situ hybridization. LMP1 expression was identified
in 83% of the EBER1- positive cases. Double-labeling studies confirmed the
localization of EBV RNA to CD15-expressing Hodgkin's cells. This study
found an extremely high prevalence of EBV in Peruvian HD, in contrast to
the much lower percentage of EBV-associated cases of HD occurring in
"Western" patients.
Volume 81,
Issue 2,
pp. 496-501,
01/15/1993
Copyright © 1993 by The American Society of Hematology
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