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Function of integrin in duodenal mucosal uptake of iron
ME Conrad, JN Umbreit, RD Peterson, EG Moore and KP Harper
Department of Medicine, Pathology and Biochemistry, University of South
Alabama, Mobile 36688.
A mechanism for the absorption of inorganic iron in the small intestine is
described in which integrins appear to play an important role in the
passage of iron across microvillous membranes. Biochemical isolates from
microvillous preparations of duodenum from rats dosed with radioiron showed
radioactivity concentrated in integrins. The presence of integrins on
mucosal surfaces of duodenal cells was confirmed by immunofluorescent
microscopy using anti-integrin monoclonal antibodies. Immunoprecipitation
methods were used to show that microvillous radioiron was precipitated with
anti-integrin antibodies and that mobilferrin, a 56-Kd cytosol iron-binding
protein, coprecipitated with integrins. We postulate from these data that
the mucosal uptake of iron from the gut lumen is mediated via an
integrin-mobilferrin pathway.
Volume 81,
Issue 2,
pp. 517-521,
01/15/1993
Copyright © 1993 by The American Society of Hematology
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