Translocation breakpoints are clustered on both chromosome 8 and chromosome
21 in the t(8;21) of acute myeloid leukemia
JE Tighe, A Daga and F Calabi
Department of Haematology, Hammersmith Hospital, London, UK.
The t(8;21)(q22;q22) is consistently associated with acute myeloid leukemia
(AML) M2. Recent data have suggested that breakpoints on chromosome 21 are
clustered within a single intron of a novel gene, AML1, just downstream of
a region of homology to the runt gene of D melanogaster. In this report, we
confirm rearrangement at the same location in at least 12 of 18 patients
with t(8;21). Furthermore, we have isolated recombinant clones spanning the
breakpoint regions on both the der(8) and the der(21) from one patient. By
using a chromosome 8 probe derived from these clones, we show that t(8;21)
breakpoints are also clustered on chromosome 8.
Volume 81,
Issue 3,
pp. 592-596,
02/01/1993
Copyright © 1993 by The American Society of Hematology
