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Soluble stem cell factor in human serum
KE Langley, LG Bennett, J Wypych, SA Yancik, XD Liu, KR Westcott, DG Chang, KA Smith and KM Zsebo
Amgen, Inc., Thousand Oaks, CA 91320.
Stem cell factor (SCF) is a recently described factor active in the early
stages of hematopoiesis. It can exist in membrane-bound form and in
proteolytically released soluble form. The levels and nature of SCF in
human serum are described. As determined by an enzyme-linked immunosorbent
assay performed for 257 samples, SCF level in serum averaged 3.3 +/- 1.1
ng/mL. The serum SCF was partially purified by immunoaffinity
chromatography and analyzed by glycosidase treatments in conjunction with
sodium dodecyl sulfate-polyacrylamide gel electrophoresis and
immunoblotting. The results show that the SCF has N- linked and O-linked
carbohydrate and corresponds to the soluble form, at or about 165 amino
acids in length. The findings suggest functional importance for soluble SCF
in humans.
Volume 81,
Issue 3,
pp. 656-660,
02/01/1993
Copyright © 1993 by The American Society of Hematology
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