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Quantitation of activated factor VII levels in plasma using a tissue factor
mutant selectively deficient in promoting factor VII activation
JH Morrissey, BG Macik, PF Neuenschwander and PC Comp
Cardiovascular Biology Research Program, Oklahoma Medical Research
Foundation, Oklahoma City 73104.
Although the majority of factor VII (FVII) circulates in the zymogen form,
low levels of activated factor VII (FVIIa) have been postulated to exist in
plasma and to serve a priming function for triggering of the clotting
cascade. However, direct measurement of plasma FVIIa has not previously
been possible. We have quantified plasma FVIIa levels using a novel, highly
sensitive assay that is free from interference by FVII. Specificity of this
clot-based assay results from the use of a mutant tissue factor that is
selectively deficient in promoting FVII activation, but retains FVIIa
cofactor function. In normal adults, FVIIa was found to be present in
plasma (mean: 3.6 ng/mL) with considerable variation between individuals
(range: 0.5 to 8.4 ng/mL). FVIIa levels were only loosely correlated with
FVII coagulant activity, but were elevated in pregnancy and reduced with
oral anticoagulant therapy. Incubation of plasma on ice in glass containers
(cold activation) resulted in substantial FVIIa generation. Measurement of
plasma forms of factor VII is of potential clinical importance because
elevated FVII coagulant activity has been implicated as a significant risk
predictor for ischemic heart disease. Clinically, this new assay will now
permit direct assessment of the role of plasma FVIIa in thrombotic
disorders.
Volume 81,
Issue 3,
pp. 734-744,
02/01/1993
Copyright © 1993 by The American Society of Hematology
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D. Green, M. A. Chamberlain, K. J. Ruth, A. R. Folsom, and K. Liu
Factor VII, Cholesterol, and Triglycerides: The CARDIA Study
Arterioscler Thromb Vasc Biol,
January 1, 1997;
17(1):
51 - 55.
[Abstract]
[Full Text]
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R. Kapur, C. J. Hoffman, V. Bhushan, and M. B. Hultin
Postprandial Elevation of Activated Factor VII in Young Adults
Arterioscler Thromb Vasc Biol,
November 1, 1996;
16(11):
1327 - 1332.
[Abstract]
[Full Text]
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A. Silveira, F. Karpe, H. Johnsson, K. A. Bauer, and A. Hamsten
In Vivo Demonstration in Humans That Large Postprandial Triglyceride-Rich Lipoproteins Activate Coagulation Factor VII Through the Intrinsic Coagulation Pathway
Arterioscler Thromb Vasc Biol,
November 1, 1996;
16(11):
1333 - 1339.
[Abstract]
[Full Text]
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P.-Y. Scarabin, A.-M. Vissac, J.-M. Kirzin, P. Bourgeat, J. Amiral, R. Agher, and L. Guize
Population Correlates of Coagulation Factor VII: Importance of Age, Sex, and Menopausal Status as Determinants of Activated Factor VII
Arterioscler Thromb Vasc Biol,
September 1, 1996;
16(9):
1170 - 1176.
[Abstract]
[Full Text]
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J. H. Chung, N. Gikakis, A. K. Rao, T. A. Drake, R. W. Colman, and L. H. Edmunds Jr
Pericardial Blood Activates the Extrinsic Coagulation Pathway During Clinical Cardiopulmonary Bypass
Circulation,
June 1, 1996;
93(11):
2014 - 2018.
[Abstract]
[Full Text]
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K. Kario, T. Matsuo, H. Kobayashi, M. Matsuo, T. Sakata, T. Miyata, and K. Shimada
Factor VII Hyperactivity and Endothelial Cell Damage Are Found in Elderly Hypertensives Only When Concomitant With Microalbuminuria
Arterioscler Thromb Vasc Biol,
March 1, 1996;
16(3):
455 - 461.
[Abstract]
[Full Text]
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Y. Jang, L. A. Guzman, A. M. Lincoff, M. Gottsauner-Wolf, F. Forudi, C. E. Hart, D. W. Courtman, M. Ezban, S. G. Ellis, and E. J. Topol
Influence of Blockade at Specific Levels of the Coagulation Cascade on Restenosis in a Rabbit Atherosclerotic Femoral Artery Injury Model
Circulation,
November 15, 1995;
92(10):
3041 - 3050.
[Abstract]
[Full Text]
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P. A. Merlini, D. Ardissino, L. Oltrona, M. Broccolino, R. Coppola, and P. M. Mannucci
Heightened Thrombin Formation but Normal Plasma Levels of Activated Factor VII in Patients With Acute Coronary Syndromes
Arterioscler Thromb Vasc Biol,
October 1, 1995;
15(10):
1675 - 1679.
[Abstract]
[Full Text]
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P Patel, M A Mendall, D Carrington, D P Strachan, E Leatham, N Molineaux, J Levy, C Blakeston, C A Seymour, A J Camm, et al.
Association of Helicobacter pylori and Chlamydia pneumoniae infections with coronary heart disease and cardiovascular risk factors
BMJ,
September 16, 1995;
311(7007):
711 - 714.
[Abstract]
[Full Text]
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K. Kario, T. Matsuo, H. Kobayashi, M. Matsuo, T. Sakata, and T. Miyata
Activation of Tissue Factor–Induced Coagulation and Endothelial Cell Dysfunction in Non–Insulin-Dependent Diabetic Patients With Microalbuminuria
Arterioscler Thromb Vasc Biol,
August 1, 1995;
15(8):
1114 - 1120.
[Abstract]
[Full Text]
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J. D. Emery, D. W. Leifer, G. L. Moura, P. Southern, J. H. Morrissey, and J. B. Lawrence
Whole-Blood Platelet Aggregation Predicts In Vitro and In Vivo Primary Hemostatic Function in the Elderly
Arterioscler Thromb Vasc Biol,
June 1, 1995;
15(6):
748 - 753.
[Abstract]
[Full Text]
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E. Moor, A. Silveira, F. van't Hooft, A. M. Suontaka, P. Eriksson, M. Blomback, and A. Hamsten
Coagulation Factor VII Mass and Activity in Young Men With Myocardial Infarction at a Young Age : Role of Plasma Lipoproteins and Factor VII Genotype
Arterioscler Thromb Vasc Biol,
May 1, 1995;
15(5):
655 - 664.
[Abstract]
[Full Text]
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T. Sakata, K. Kario, T. Matsuo, Y. Katayama, T. Matsuyama, H. Kato, and T. Miyata
Suppression of Plasma-Activated Factor VII Levels by Warfarin Therapy
Arterioscler Thromb Vasc Biol,
February 1, 1995;
15(2):
241 - 246.
[Abstract]
[Full Text]
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B. J. Warn-Cramer and S. I. Rapaport
Evidence Suggestive of Activation of the Intrinsic Pathway of Blood Coagulation After Injection of Factor Xa/Phospholipid Into Rabbits
Arterioscler Thromb Vasc Biol,
January 1, 1995;
15(1):
133 - 139.
[Abstract]
[Full Text]
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