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Interleukin-11 acts as an autocrine growth factor for human
megakaryoblastic cell lines
S Kobayashi, M Teramura, I Sugawara, K Oshimi and H Mizoguchi
Department of Hematology, Tokyo Women's Medical College, Japan.
The cytokine interleukin-11 (IL-11) promotes normal human
megakaryocytopoiesis in vitro. However, its role in abnormal
megakaryocytopoiesis is not well known. Accordingly, we studied its effects
on human megakaryoblastic cell lines CMK and Meg-J. IL-11 stimulated the
proliferation of CMK and Meg-J in a dose-dependent manner with maximal
growth being achieved at the concentration of 50 and 500 ng/mL,
respectively. The growth of the cells was inhibited by anti-IL-11 antibody
and IL-11 antisense oligonucleotides. IL-11 transcripts were detected in
these two cell lines using a reverse transcriptase-polymerase chain
reaction assay. These findings indicate that IL-11 might be an autocrine
growth factor for megakaryoblastic cells. IL-11 transcripts also existed in
other leukemia cell lines: HL- 60, U937, and K562. However, the growth of
these cells was not stimulated by IL-11, and was not inhibited by IL-11
antisense oligonucleotides. These results suggested that IL-11 might
regulate malignant cells of the megakaryocytic lineage, in part by an
autocrine loop.
Volume 81,
Issue 4,
pp. 889-893,
02/15/1993
Copyright © 1993 by The American Society of Hematology
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