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In vivo effects of recombinant interleukin-11 on myelopoiesis in mice
G Hangoc, T Yin, S Cooper, P Schendel, YC Yang and HE Broxmeyer
Department of Medicine (Hematology/Oncology), Indiana University School of
Medicine, Indianapolis.
Purified recombinant human interleukin-11 (rhuIL-11) was assessed for its
in vivo effects on the proliferation and differentiation of hematopoietic
progenitors as well as its capacity to accelerate the recovery of a
drug-suppressed hematopoietic system. Dosage and time sequence studies
demonstrated that administration of IL-11 to normal mice resulted in
increases in absolute numbers of femoral marrow and splenic myeloid
(granulocyte-macrophage colony-forming unit [CFU-GM], burst-forming
unit-erythroid [BFU-E], CFU-granulocyte, erythroid, macrophage,
megakaryocyte) progenitor cells and in stimulation of these progenitors to
a higher cell cycling rate. This was associated with increased numbers of
circulating neutrophils. Administration of IL-11 to mice pretreated with
cyclophosphamide decreased the time required to regain normal levels of
neutrophil and platelet counts in peripheral blood. In addition, IL-11
accelerated reconstitution to normal range of myeloid progenitors from bone
marrow and spleen of myelosuppressed mice. These data suggest that IL-11
may play an important role in the regulation of hematopoiesis, and the
application of this novel cytokine may have clinical therapeutic benefits.
Volume 81,
Issue 4,
pp. 965-972,
02/15/1993
Copyright © 1993 by The American Society of Hematology
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