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Interleukin-4 protects double-negative and CD4 single-positive thymocytes
from dexamethasone-induced apoptosis
G Migliorati, I Nicoletti, MC Pagliacci, L D'Adamio and C Riccardi
Instituto di Farmacologia Medica, Perugia University Medical School, Italy.
Glucocorticoid hormones (GCH) and anti-CD3 monoclonal antibodies (MoAbs)
induce in mouse thymocytes and T-cell tumor lines an active process of cell
death called apoptosis. Interleukins (IL), including IL- 1 and IL-2, have
been reported to inhibit such apoptosis. In this study we show that IL-4
also reduced the DNA fragmentation characteristic of dexamethasone
(DEX)-induced apoptosis in thymocytes. This effect, studied in both
time-course and dose-response experiments, was also detected at low IL-4
concentrations (1 U/mL) and against high DEX levels (10(-7) mol/L). The
effect of IL-4 was blocked by an anti-IL-4 but not by an anti-IL-1 alpha
MoAb, and was thus both specific and direct. Phenotypic analysis showed
that IL-4 protects predominantly CD4- CD8- and CD4+CD8- cells. Our findings
suggest that intrathymic T-cell development may be influenced by IL-4.
Volume 81,
Issue 5,
pp. 1352-1358,
03/01/1993
Copyright © 1993 by The American Society of Hematology
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