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Inactivation of interleukin-8 by the C5a-inactivating protease from serosal
fluid
SK Ayesh, Y Azar, BM Babior and Y Matzner
Hematology Unit, Hadassah University Hospital, Mount Scopus, Jerusalem,
Israel.
The complement fragment C5a and the cytokine interleukin-8 (IL-8) are
proinflammatory peptides with potent chemotactic activity toward
neutrophils. We have previously shown that C5a can be inactivated by a
protease that is found in normal synovial and peritoneal fluids but is
absent from serosal fluids obtained from patients with familial
Mediterranean fever (FMF). We report here that serosal fluids can also
eliminate the chemotactic activity of IL-8. The agent responsible for IL-8
elimination appears to be the C5a-inactivating protease, because the pure
protease can inactivate IL-8, inactivation of IL-8 by normal peritoneal
fluid is partly prevented by an antibody raised against the purified
C5a-inactivating protease, and IL-8 is not inactivated by peritoneal fluids
from patients with FMF. The ability of this protease to inactivate both,
early (C5a) and late (IL-8) inflammatory mediators identifies it as a
potentially significant regulator of inflammation.
Volume 81,
Issue 6,
pp. 1424-1427,
03/15/1993
Copyright © 1993 by The American Society of Hematology
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