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Tyrosine phosphorylation of guanosine triphosphatase activating protein by activation via surface IgG in human B cells

H Yagura, N Oyaizu and S Pahwa

Department of Pediatrics/Immunology, North Shore University Hospital- Cornell University Medical College, Manhasset, NY 11030.

In this study, we analyzed tyrosine phosphorylation of guanosine triphosphatase (GTPase) activating protein in human B cells stimulated through surface IgG, using Western blot and immunoprecipitation. Stimulation through surface IgG induced the tyrosine phosphorylation of GTPase-activating protein (GAP) and two associated proteins, a 190-Kd protein and a 62-Kd protein, within 1 minute and in a dose-dependent manner. This tyrosine phosphorylation was blocked by Genistein (Extrasynthese, Genay, France). These data suggest that GTPase- activating protein is involved in a signal transduction pathway initiated from surface IgG in human B cells.

Volume 81, Issue 6, pp. 1535-1539, 03/15/1993
Copyright © 1993 by The American Society of Hematology


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  Copyright © 1993 by American Society of Hematology         Online ISSN: 1528-0020