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The 8;21 chromosome translocation in acute myeloid leukemia is always
detectable by molecular analysis using AML1
N Maseki, H Miyoshi, K Shimizu, C Homma, M Ohki, M Sakurai and Y Kaneko
Third Clinical Department, Saitama Cancer Center Hospital, Japan.
The AML1 gene was rearranged in leukemic cells with t(8;21)(q22;q22) or its
variant, complex t(8;V;21) translocations from 33 acute myeloid leukemia
(AML) patients. The AML1 rearrangement was also detected in three AML
patients without t(8;21); two had a normal diploid karyotype, and one had a
karyotype of 45,X, - X. The AML1 rearrangement in the t(8;21) breakpoint
cluster region was not detected in leukemic cells with cytogenetic
abnormalities other than t(8;21), or with normal diploidy obtained from 23
AML patients. Because leukemic cells of the five patients with complex
t(8;V;21) translocations had a der(8)t(8;21) chromosome with a break in
band 8q22 in common, the juxtaposition of the 5' side of AML1 to a
predicted counterpart gene located in the breakpoint region of 8q22 may be
an essential step in the leukemogenesis of AML with t(8;21). Our findings
show that the 8;21 translocation, its variants, and the masked t(8;21) may
all be detectable by the Southern hybridization method using the AML1
probes.
Volume 81,
Issue 6,
pp. 1573-1579,
03/15/1993
Copyright © 1993 by The American Society of Hematology
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