|
|
 Previous Article | Table of Contents | Next Article 
Protein S deficiency in men with long-term human immunodeficiency virus
infection [see comments]
CP Stahl, CS Wideman, TJ Spira, EC Haff, GJ Hixon and BL Evatt
Division of HIV/AIDS, National Center for Infectious Diseases, Centers for
Disease Control and Prevention, Atlanta, GA 30333.
Decreases in protein S levels have recently been reported in some human
immunodeficiency virus (HIV)-infected patients. To examine predisposing
factors, 25 men randomly selected from a long-term study of HIV- infected
patients were studied. The minimum mean duration of HIV seropositivity in
this group was 106.6 months (range 15 to 143 months). No patients were
anticoagulated at the time of the study. Three of the 25 randomly selected
patients gave a history of thrombosis, in each instance occurring after the
onset of HIV positivity. Two of the 3 patients with thrombosis had more
than one episode. Coagulation studies showed that 3 of 3 (100%) of the
patients with thrombosis and 16 of 22 (72.7%) of those without previous
thrombosis had decreased free protein S. Mean-free and total protein S
levels were statistically lower for HIV-infected patients with and without
previous thrombosis compared with healthy male controls. C4b-binding
protein was not increased in study patients with decreased protein S
levels. Decreases in protein S levels did not correlate with CD4+ cell
levels, CDC class, p24 antigen positivity, zidovudine (AZT) use, or
Pneumocystis carinii prophylaxis. The duration of disease statistically
correlated with decreases in protein S levels (r = .37, P < .05). A
linear correlation existed between increasing IgG anticardiolipin antibody
levels and decreasing free protein S antigen (r = .67, P < .005). This
study shows that protein S deficiency is common in long-term HIV-infected
patients and is caused by a decrease in the free protein, rather than by
changes in the bound complex. The data suggest that protein S deficiency is
not correlated with HIV disease severity but may predispose patients to
thromboembolic complications.
Volume 81,
Issue 7,
pp. 1801-1807,
04/01/1993
Copyright © 1993 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K Yoganathan and A Benton
Haemorrhagic transformation of cerebral infarction in an AIDS patient - thrombophaelia screen essential!
Int J STD AIDS,
November 1, 2009;
20(11):
801 - 802.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Richardson, A. M. Hill, C. J. C. Johnston, A. McGregor, A. R. Norrish, D. Eastwood, and C. B. D. Lavy
Fracture healing in HIV-positive populations
J Bone Joint Surg Br,
August 1, 2008;
90-B(8):
988 - 994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. M. Lijfering, H. G. Sprenger, R. R. Georg, P. A. van der Meulen, and J. van der Meer
Relationship between Progression to AIDS and Thrombophilic Abnormalities in HIV Infection
Clin. Chem.,
July 1, 2008;
54(7):
1226 - 1233.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Y. Hsue and D. D. Waters
What a Cardiologist Needs to Know About Patients With Human Immunodeficiency Virus Infection
Circulation,
December 20, 2005;
112(25):
3947 - 3957.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A Mochan, M Modi, and G Modi
Protein S deficiency in HIV associated ischaemic stroke: an epiphenomenon of HIV infection
J. Neurol. Neurosurg. Psychiatry,
October 1, 2005;
76(10):
1455 - 1456.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-M. P. Shen and E. P. Frenkel
Thrombosis and a Hypercoagulable State in HIV-Infected Patients
Clinical and Applied Thrombosis/Hemostasis,
July 1, 2004;
10(3):
277 - 280.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. M. Rezende, R. E. Simmonds, and D. A. Lane
Coagulation, inflammation, and apoptosis: different roles for protein S and the protein S-C4b binding protein complex
Blood,
February 15, 2004;
103(4):
1192 - 1201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Majluf-Cruz, M. Silva-Estrada, R. Sanchez-Barboza, G. Montiel-Manzano, S. Trevino-Perez, M. Santoscoy-Gomez, A. R. de Chavez-Ochoa, N. C.-d. la Penna, and L. Nieto-Cisneros
Venous Thrombosis Among Patients with AIDS
Clinical and Applied Thrombosis/Hemostasis,
January 1, 2004;
10(1):
19 - 25.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. Levi, T. T Keller, E. van Gorp, and H. ten Cate
Infection and inflammation and the coagulation system
Cardiovasc Res,
October 15, 2003;
60(1):
26 - 39.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. T Keller, A. T.A Mairuhu, M. D de Kruif, S. K Klein, V. E.A Gerdes, H. ten Cate, D. P.M Brandjes, M. Levi, and E. C.M van Gorp
Infections and endothelial cells
Cardiovasc Res,
October 15, 2003;
60(1):
40 - 48.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Erbe, V. Rickerts, R. M. Bauersachs, and E. Lindhoff-Last
Acquired Protein C and Protein S Deficiency in HIV-Infected Patients
Clinical and Applied Thrombosis/Hemostasis,
October 1, 2003;
9(4):
325 - 331.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. R Deitcher and M. P. Gomes
Hypercoagulable state testing and malignancy screening following venous thromboembolic events
Vascular Medicine,
February 1, 2003;
8(1):
33 - 46.
[Abstract]
[PDF]
|
|
|
|
|
|
|
A. Mochan, M. Modi, and G. Modi
Stroke in Black South African HIV-Positive Patients: A Prospective Analysis
Stroke,
January 1, 2003;
34(1):
10 - 15.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. M. Gaughan, L. M. Mofenson, M. D. Hughes, G. R. Seage III, G. L. Ciupak, and J. M. Oleske
Osteonecrosis of the Hip (Legg-Calve-Perthes Disease) in Human Immunodeficiency Virus-Infected Children
Pediatrics,
May 1, 2002;
109(5):
e74 - 74.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. I. Qureshi, R. S. Janssen, J. M. Karon, J. P. Weissman, M. S. Akbar, K. Safdar, and M. R. Frankel
Human Immunodeficiency Virus Infection and Stroke in Young Patients
Arch Neurol,
September 1, 1997;
54(9):
1150 - 1153.
[Abstract]
[PDF]
|
|
|
|
|
|
|
D. R. Duerksen, A. Ahmad, J. Doweiko, B. R. Bistrian, and E. A. Mascioli
Risk of Symptomatic Central Venous Thrombotic Complications in AIDS Patients Receiving Home Parenteral Nutrition
JPEN J Parenter Enteral Nutr,
July 1, 1996;
20(4):
302 - 305.
[Abstract]
[PDF]
|
|
|
|
|
