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Induction of monocytic differentiation and tumorigenicity by v-Ha-ras in
differentiation arrested hematopoietic cells
S Hibi, J Lohler, J Friel, C Stocking and W Ostertag
Heinrich-Pette-Institut fur Experimentelle Virologie und Immunologie an der
Universitat Hamburg, Germany.
Activated ras genes are often associated with human myeloid leukemias with
a monocytic differentiated phenotype. To investigate the role of the
activated ras gene in leukemogenesis, a myeloid nontumorigenic cell line
(FDC-P1) was infected with a selectable retroviral vector carrying the
v-Ha-ras gene (H1neo). Infected FDC-P1 cells were not only tumorigenic, but
also showed increased monocytic differentiation in vitro. Monocytic
differentiation and tumorigenicity in vivo were correlated with
several-fold increased levels of activated ras gene expression. Tumorigenic
cells were arrested with respect to monocytic marker expression at a much
later stage of macrophage differentiation than the parental noninfected
FDC-P1 cells. These data thus suggest a model of how activated ras genes
could be involved in the preferential induction of hematopoietic
malignancies with a myelomonocytic phenotype.
Volume 81,
Issue 7,
pp. 1841-1848,
04/01/1993
Copyright © 1993 by The American Society of Hematology
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