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Allogeneic blood transfusion-induced enhancement of tumor growth: two
animal models showing amelioration by leukodepletion and passive transfer
using spleen cells [see comments]
MA Blajchman, L Bardossy, R Carmen, A Sastry and DP Singal
Department of Pathology, Faculty of Health Sciences, McMaster University,
Hamilton, Ontario, Canada.
Allogeneic blood transfusions have been reported to induce immunomodulation
in recipients of blood products. While the mechanism(s) of this
immunomodulatory effect is unknown, it has been suggested that this effect
of allogeneic blood transfusions could adversely affect patients with a
malignant disorder. These concerns have been supported by a number of
nonrandomized, mainly retrospective, clinical studies which indicate that
allogeneic blood transfusions can adversely affect prognosis following the
surgical treatment of oncology patients. Recently, we have shown that
allogeneic blood transfusions enhance primary tumor growth and increase
metastatic pulmonary nodule formation in inbred mice. The tumor
growth-promoting activity of allogeneic blood transfusions was studied also
using outbred rabbits. In this present study, we demonstrate that the tumor
growth-promoting effect of allogeneic blood transfusions is mediated by
donor leukocytes and that this effect can be abolished by their removal
before transfusion. We show also that the allogeneic blood transfusion
tumor growth-promoting effect can be passively transferred to naive animals
(both mice and rabbits) using spleen cells from allogeneically transfused
animals. In these experiments, numbers of metastatic pulmonary nodules were
significantly increased in both mice and rabbits that had received spleen
cells from allogeneically transfused animals compared with those that had
received spleen cells from syngeneically transfused animals, or from
animals that had been transfused with leukodepleted allogeneic blood.
Volume 81,
Issue 7,
pp. 1880-1882,
04/01/1993
Copyright © 1993 by The American Society of Hematology
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