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Autoimmune neutropenia [see comments]
KA Shastri and GL Logue
Department of Medicine, State University of New York, Buffalo.
There have been several new developments in the field of autoimmune
neutropenia over the past decade. Neutropenia caused by antibodies directed
against granulocyte precursor cells, the oligoclonal nature of
antineutrophil antibodies, and the expanding knowledge of neutrophil
antigens, particularly in relationship to autoantibodies, are exciting new
areas of investigation. Knowledge has also been advanced in the effector
mechanisms of neutrophil autoantibodies and the effect of autoantibodies on
the neutrophil function. In addition, some clinical syndromes of immune
neutropenia have been better defined over the past decade, such as
autoimmune neutropenia of infancy and chronic idiopathic neutropenia in
adults. The past decade also saw interesting developments in the treatment
of immune neutropenia, particularly in the use of gammaglobulin
preparations and more recently in the advent of hematopoietic growth
factors. This review focuses on these newer aspects of autoimmune
neutropenia.
Volume 81,
Issue 8,
pp. 1984-1995,
04/15/1993
Copyright © 1993 by The American Society of Hematology

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