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 Previous Article | Table of Contents | Next Article 
Granulocyte colony-stimulating factor "mobilized" peripheral blood
progenitor cells accelerate granulocyte and platelet recovery after
high-dose chemotherapy
NJ Chao, JR Schriber, K Grimes, GD Long, RS Negrin, CM Raimondi, SJ Horning, SL Brown, L Miller and KG Blume
Department of Medicine, Stanford University Medical Center, CA 94305.
Hematopoietic growth factors have been used to accelerate engraftment after
bone marrow transplantation and to "mobilize" peripheral blood progenitor
cells (PBPC). We report on the data in 85 consecutive patients with
Hodgkin's disease who were treated in a single institution using different
methods to obtain PB progenitor cells. Use of granulocyte
colony-stimulating factor for mobilization resulted in a significantly
accelerated time to recovery of granulocytes (10 days v 12 days, P <
.01) when compared with "nonmobilized" PBPC recipients. Similarly, use of
mobilized PBPC resulted in a significantly accelerated time to platelet
engraftment (13 days v 30 days, P < .001) when compared with
"nonmobilized" recipients. Moreover, there was a statistically significant
difference in total costs in favor of the group receiving "mobilized" PBPC.
Volume 81,
Issue 8,
pp. 2031-2035,
04/15/1993
Copyright © 1993 by The American Society of Hematology
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