|
|
 Previous Article | Table of Contents | Next Article 
Coregulation of the APO-1 antigen with intercellular adhesion molecule- 1
(CD54) in tonsillar B cells and coordinate expression in follicular center
B cells and in follicle center and mediastinal B-cell lymphomas
P Moller, C Henne, F Leithauser, A Eichelmann, A Schmidt, S Bruderlein, J Dhein and PH Krammer
Institute of Pathology, University of Heidelberg, Germany.
APO-1 is a 48-Kd transmembrane glycoprotein identical to the Fas antigen
and belongs to the nerve growth factor (NGF)/tumor necrosis factor (TNF)
receptor family of surface molecules. Cross-linking of APO- 1 induces
apoptotic cell death in sensitive cells. We show here that APO-1 is an
activation molecule on B cells. It was induced/enhanced on dense and
buoyant tonsillar B cells, respectively, through surface Ig cross-linking
in combination with interleukin-2 or by interferon-gamma together with
tumor necrosis factor-alpha. These conditions also increased the amount of
intercellular adhesion molecule-1 (CD54) on these cells. Epstein-Barr virus
transformants of peripheral B cells coexpressed APO-1 and CD54 at very high
levels. Immunohistologically, Apo-1 was detectable at low levels in a
subpopulation of follicle center B blasts and, at higher levels, in
sinusoidal B cells. APO-1 was undetectable in follicular mantle B cells and
plasma cells. In isolated tonsillar B cells, APO-1 was expressed in CD10+
follicle center cells. In acute B lymphoblastic leukemia, chronic B
lymphocytic leukemia, and Burkitt's lymphomas, APO-1 and CD54 molecules
were immunohistochemically undetectable. Coordinate expression of these
antigens was found in mediastinal B-cell lymphomas. The mode of APO-1 and
CD54 expression was correlated in follicle center cell lymphomas (P <
.0019), but less stringently in hairy cell leukemia. No association was
found in plasmacytomas. This was in line with the differential expression
of these molecules found in reactive plasma cells. Expression of APO-1 in B
cells of different stages of differentiation and, correspondingly, in
certain B-cell neoplasias might suggest a role of this molecule in the
induction of B-cell apoptosis. This function might be influenced by CD54
and CD54-mediated signals.
Volume 81,
Issue 8,
pp. 2067-2075,
04/15/1993
Copyright © 1993 by The American Society of Hematology
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
K. J. Savage, S. Monti, J. L. Kutok, G. Cattoretti, D. Neuberg, L. de Leval, P. Kurtin, P. D. Cin, C. Ladd, F. Feuerhake, et al.
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma
Blood,
December 1, 2003;
102(12):
3871 - 3879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Greil, G. Anether, K. Johrer, and I. Tinhofer
Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools
J. Leukoc. Biol.,
September 1, 2003;
74(3):
311 - 330.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Straus, E. S. Jaffe, J. M. Puck, J. K. Dale, K. B. Elkon, A. Rosen-Wolff, A. M. J. Peters, M. C. Sneller, C. W. Hallahan, J. Wang, et al.
The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis
Blood,
July 1, 2001;
98(1):
194 - 200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Choe, L. Li, X. Zhang, C. D. Gregory, and Y. S. Choi
Distinct Role of Follicular Dendritic Cells and T Cells in the Proliferation, Differentiation, and Apoptosis of a Centroblast Cell Line, L3055
J. Immunol.,
January 1, 2000;
164(1):
56 - 63.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Strater, S. M. Mariani, H. Walczak, F. G. Rucker, F. Leithauser, P. H. Krammer, and P. Moller
CD95 Ligand (CD95L) in Normal Human Lymphoid Tissues : A Subset of Plasma Cells Are Prominent Producers of CD95L
Am. J. Pathol.,
January 1, 1999;
154(1):
193 - 201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Spets, P. Georgii-Hemming, J. Siljason, K. Nilsson, and H. Jernberg-Wiklund
Fas/APO-1 (CD95)-Mediated Apoptosis Is Activated by Interferon-gamma and Interferon-alpha in Interleukin-6 (IL-6)-Dependent and IL-6-Independent Multiple Myeloma Cell Lines
Blood,
October 15, 1998;
92(8):
2914 - 2923.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Plumas, M.-C. Jacob, L. Chaperot, J.-P. Molens, J.-J. Sotto, and J.-C. Bensa
Tumor B Cells From Non-Hodgkin's Lymphoma Are Resistant to CD95 (Fas/Apo-1)-Mediated Apoptosis
Blood,
April 15, 1998;
91(8):
2875 - 2885.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. D. D'Souza, B. Bonetti, V. Balasingam, N. R. Cashman, P. A. Barker, A. B. Troutt, C. S. Raine, and J. P. Antel
Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death
J. Exp. Med.,
December 1, 1996;
184(6):
2361 - 2370.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S Nagata and P Golstein
The Fas death factor
Science,
March 10, 1995;
267(5203):
1449 - 1456.
[Abstract]
[PDF]
|
|
|
|
|
