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Elevated interleukin-8 serum concentrations in beta-thalassemia and
graft-versus-host disease
M Uguccioni, R Meliconi, S Nesci, G Lucarelli, M Ceska, G Gasbarrini and A Facchini
Laboratorio Immunologia e Genetica, Istituto di Ricerca Codivilla- Putti,
IOR, Bologna, Italy.
Neutrophil chemotactic and functional defects occur in beta-thalassemia and
in patients after bone marrow transplantation (BMT). Interleukin-8 (IL-8)
is a novel chemotactic and activating peptide for neutrophils and can be
detected in the circulation. IL-8 serum concentrations were evaluated in 30
beta-thalassemic patients before and after BMT. Serial samples from 16
patients were also studied. Fourteen sera from healthy children, 43
patients with chronic viral hepatitis, 16 patients on chronic transfusion
treatment for various hematologic disorders, and 28 healthy adults were
studied as controls. IL-8 was evaluated by an enzyme-linked immunosorbent
assay. Patients with beta-thalassemia had higher IL-8 concentrations than
did normal controls, patients with liver disease, and patients on chronic
transfusion. beta-Thalassemic patients with severe liver siderosis and
fibrosis had the highest IL-8 concentrations. After BMT in patients with
successful engraftment, IL-8 concentrations decreased significantly. In
contrast, in patients with acute graft-versus-host disease (GVHD), IL-8
concentrations were not statistically different from the concentrations
found before BMT and were higher than in patients with no complications and
patients with graft rejection. IL-8 may play a part in the immune
dysregulation that occurs in beta-thalassemia and may be involved in the
immune mechanisms leading to GVHD.
Volume 81,
Issue 9,
pp. 2252-2256,
05/01/1993
Copyright © 1993 by The American Society of Hematology
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