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Expression of HERV-K proviruses in human leukocytes
I Brodsky, B Foley, D Haines, J Johnston, K Cuddy and D Gillespie
Department of Neoplastic Diseases, Hahnemann University, Philadelphia, PA
19102-1192.
HERV-K is a 50-copy, human endogenous, class 1 retroviral element that
contains some polycistrons with gag, pol, and env open reading frames.
Although expression of HERV-K proviruses has been shown in cultured human
cell lines, expression of these elements has not been shown in human blood
leukocytes. Using both reverse transcriptase-polymerase chain reaction and
ribonuclease protection techniques, we show HERV-K pol gene expression in
human blood leukocytes. Expression in blood leukocytes from 7 normal
individuals was from a variety of different HERV-K proviruses, while
restricted expression was observed in blood cells of 5 leukemia patients
and 3 polycythemia vera patients. Evidence is presented suggesting that the
restricted expression in leukemia blood cells is a result of gene
regulation, not gene amplification.
Volume 81,
Issue 9,
pp. 2369-2374,
05/01/1993
Copyright © 1993 by The American Society of Hematology
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