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Phenotypic diversity of natural killer (NK) populations in patients with
NK-type lymphoproliferative disease of granular lymphocytes
R Zambello, L Trentin, E Ciccone, P Bulian, C Agostini, A Moretta, L Moretta and G Semenzato
Istituto di Medicina Clinica, Universita di Padova, Italy.
Using monoclonal antibodies (MoAbs) termed GL183 and EB6, directed to a
novel family of natural killer (NK) specific triggering molecules, four
functional subsets of NK cells have been recently defined (GL183+EB6-;
GL183+EB6+; GL183-EB6+; GL183-EB6-). In healthy individuals, all these
subsets are represented in variable portion. The expression of EB6 and
GL183 surface antigens has been analyzed in a series of 14 patients with
lymphoproliferative disease of granular lymphocytes (LDGL) characterized by
a chronic CD3-CD16+ lymphocytosis. Our data showed that in 11 of 14 cases,
the proliferation was specifically sustained by one of the four possible
subsets of granular lymphocytes (GLs) (seven cases: EB6-GL183-; three
cases: EB6+GL183-; one case: EB6-GL183+). In the remaining three cases, a
pattern was demonstrated that is consistent with that of healthy
individuals (ie, the presence of all four subsets). When expressed on GL
surfaces, in the majority of cases tested both EB6 and GL183 MoAbs behave
as functional surface molecules as assessed in the redirected killing of
P815 target cells. We also provided evidence that EB6+GL183+ proliferating
cells show a definite (type 1) in vitro NK specificity as do their normal
counterparts. The unique expansion of a defined subset of NK cells in most
patients with LDGL suggests that the pathologic noxa leading to GL
proliferation selectively acts on a specific subset of NK lymphocytes.
Volume 81,
Issue 9,
pp. 2381-2385,
05/01/1993
Copyright © 1993 by The American Society of Hematology
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