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Next Article 
Clonal diseases of large granular lymphocytes [see comments]
TP Loughran
Veterans Administration Hospital, Syracuse, NY 13210.
Three distinct clinical syndromes occur in patients with increased numbers
of circulating LGL. Patients with T-LGL leukemia have clonal proliferations
of CD3+ LGL typically associated with chronic neutropenia and autoimmune
features. NK-LGL leukemia is characterized by clonal CD3- LGL proliferation
with an acute clinical presentation marked by massive hepatosplenomegaly
and systemic illness. However, most patients with increased numbers of CD3-
LGL do not have clinical features of NK-LGL leukemia and have a chronic
clinical course. X- linked gene analyses have supported a polyclonal LGL
lymphocytosis in this syndrome. Further studies are needed to determine
whether clonal progression can occur in these patients.
Volume 82,
Issue 1,
pp. 1-14,
07/01/1993
Copyright © 1993 by The American Society of Hematology
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