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Frequent latent Epstein-Barr virus infection of neoplastic T cells and
bystander B cells in human immunodeficiency virus-negative European
peripheral pleomorphic T-cell lymphomas
P Korbjuhn, I Anagnostopoulos, M Hummel, M Tiemann, F Dallenbach, MR Parwaresch and H Stein
Konsultations und Referenzzentrum fur Lymphknotenund Hamatopathologie am
Institut fur Pathologie, Klinikum Steglitz, Freie Universitat, Berlin,
Germany.
We investigated 81 cases of peripheral pleomorphic T-cell lymphoma (PMTCL)
occurring in human immunodeficiency virus-negative Europeans for the
presence of Epstein-Barr virus (EBV)-DNA through polymerase chain reaction
(PCR) for the presence of EBV-encoded small nuclear RNAs (EBER) and
immediate early mRNAs (Bam H-fragment, lower strand frame [BHLF]) by in
situ hybridization (ISH) and for EBV-encoded latent membrane protein (LMP)
and nuclear antigen 2 (EBNA2) by immunohistology (IH). EBER-ISH, which
could be applied on all cases, showed an overall incidence of EBV-infected
cells in 38 of 81 cases (47%) of PMTCL. These data could be confirmed by
PCR, which produced congruent results in the cases with amplifiable DNA. By
EBER-ISH, the virus was located in the tumor cells in 30 of the 38
EBV-positive cases, with the proportion of the infected cells ranging from
1% to 100%. In 18 of these cases and in the 8 cases without EBV-infected
tumor cells, the virus was, respectively, either additionally or
exclusively detectable in occasional nonmalignant lymphoid bystander cells.
An LMP expression was observed in several of the EBER-expressing tumor
cells in 18 cases, whereas EBNA2 was detectable only in one case, which
also displayed signs of viral replication. Some nonmalignant EBV-infected B
immunoblasts also expressed LMP in several cases. Primary cutaneous and
enteropathy-associated PMTCL displayed less frequent EBV infection when
compared with other extranodal or nodal manifestations.
Volume 82,
Issue 1,
pp. 217-223,
07/01/1993
Copyright © 1993 by The American Society of Hematology
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