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Next Article 
Deletions within the LMP1 oncogene of Epstein-Barr virus are clustered in
Hodgkin's disease and identical to those observed in nasopharyngeal
carcinoma
H Knecht, E Bachmann, P Brousset, K Sandvej, D Nadal, F Bachmann, BF Odermatt, G Delsol and G Pallesen
Department of Internal Medicine, CHUV University Hospital, Lausanne,
Switzerland.
This study of 52 European patients with Hodgkin's disease (HD) expressing
the latent membrane protein 1 (LMP1) oncogene within diagnostic Hodgkin and
Reed-Sternberg (HRS) cells was performed to detect LMP1 isolates carrying
deletions and to characterize them at a molecular and histologic level.
Deletions were identified in 5 cases, clustered near the 3' end of the LMP1
gene, and histologically associated with numerous HRS cells. DNA sequencing
showed homology with the deletions seen in the Asian nasopharyngeal
carcinoma (NPC) isolates CAO and 1510. Our findings suggest that partial
deletions of the LMP1 oncogene, associated with aggressive behavior in NPC
CAO and NPC 1510, occur at a particular localization and confer a
proliferative phenotype to lymphoid cells in HD.
Volume 82,
Issue 10,
pp. 2937-2942,
11/15/1993
Copyright © 1993 by The American Society of Hematology
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