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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by van der Reijden, B. A. Articles by Breuning, M. H. Search for Related Content PubMed PubMed Citation Articles by van der Reijden, B. A. Articles by Breuning, M. H. Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  A gene for a myosin peptide is disrupted by the inv(16)(p13q22) in acute nonlymphocytic leukemia M4Eo BA van der Reijden, JG Dauwerse, JW Wessels, GC Beverstock, A Hagemeijer, GJ van Ommen and MH Breuning Department of Human Genetics, Leiden University, The Netherlands. Chromosome 16 aberrations are well known in acute nonlymphocytic leukemia (ANLL). The most frequent chromosome 16 aberration in ANLL subtype M4Eo is the inv(16)(p13q22). Recently, we showed that in 5 inv(16) patients with ANLL M4Eo the short arm breakpoints are clustered within a 14-kb genomic EcoRI fragment. We report here the identification of a gene situated in the 14-kb fragment. The gene, which codes for a myosin peptide, is disrupted by the inversion of chromosome 16 in the 5 patients. To the best of our knowledge, this is the first report of a myosin gene disrupted in leukemia. Volume 82, Issue 10, pp. 2948-2952, 11/15/1993 Copyright © 1993 by The American Society of Hematology CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: C. M. McHale, J. L. Wiemels, L. Zhang, X. Ma, P. A. Buffler, J. Feusner, K. Matthay, G. Dahl, and M. T. Smith Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16) Blood, June 1, 2003; 101(11): 4640 - 4641. [Full Text] [PDF] D. S. Viswanatha, I.-M. Chen, P. P. Liu, M. L. Slovak, C. Rankin, D. R. Head, and C. L. Willman Characterization and Use of an Antibody Detecting the CBFbeta -SMMHC Fusion Protein in inv(16)/t(16;16)-Associated Acute Myeloid Leukemias Blood, March 15, 1998; 91(6): 1882 - 1890. [Abstract] [Full Text] [PDF]

	Copyright © 1993 by American Society of Hematology         Online ISSN: 1528-0020