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Hematopoietic lineage- and stage-restricted expression of the ETS oncogene
family member PU.1
R Hromas, A Orazi, RS Neiman, R Maki, C Van Beveran, J Moore and M Klemsz
Department of Medicine, Walther Oncology Center, Indiana University Medical
Center, Indianapolis 46252-5121.
The ETS oncogene family member PU.1 is a transcriptional activator that is
dysregulated by Friend erythroleukemia virus insertion. Northern analysis
found that PU.1 is highly expressed in cells of myeloid and B- lymphoid
origin, but not expressed at all in a number of nonhematopoietic tissues.
Interferon-gamma and retinoic acid downregulated PU.1 expression in marrow
macrophages. In situ immunohistochemistry found that PU.1 is expressed only
in early granulocytic and erythroid cells and megakaryocytes, but not in
mature erythroid cells, mature granulocytes, endothelial cells, or
osteocytes. Thus, its expression pattern makes PU.1 a candidate for a
genetic determinant of lineage commitment and stage progression in blood
cell development. It also lends insight into how PU.1 might play a role in
Friend virus erythroleukemia.
Volume 82,
Issue 10,
pp. 2998-3004,
11/15/1993
Copyright © 1993 by The American Society of Hematology
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