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Serum concentrations of granulocyte colony-stimulating factor in healthy
term and preterm neonates and in those with various diseases including
bacterial infections
P Gessler, N Kirchmann, R Kientsch-Engel, N Haas, P Lasch and W Kachel
Department of Pediatrics, University Hospital of Mannheim, Germany.
The neonate is uniquely susceptible to severe and overwhelming bacterial
infections. One of the most important deficits in the neonatal host defense
system seems to be a quantitative and qualitative deficiency of the myeloid
and the phagocytic system. Future optimal therapy of neonatal sepsis may
include the use of adjuvant immunologic therapy. Granulocyte
colony-stimulating factor (G-CSF) has been shown to induce neutrophilia and
to enhance mature effector neutrophil function. To evaluate the role of
G-CSF with respect to infection, we examined serum levels of G-CSF in term
and preterm neonates, using an enzyme-linked immunosorbent assay method.
G-CSF levels in healthy neonates showed peak levels up to 7 hours after
birth, followed by an increase in total neutrophil cell (TNC) counts. Both
G-CSF levels determined between 4 and 7 hours after birth and peak TNC
counts correlated with the gestational age of the neonates. The state of
nutrition, maternal treatment with glucocorticoids, maternal infection and
hypertension, and the mode of delivery influenced peak G-CSF levels.
Neonates with signs of infection between 4 and 7 hours after birth had
higher levels of G-CSF than did healthy neonates (1,312 +/- 396 pg/mL v 176
+/- 19 pg/mL). In conclusion, the presented results of serum concentrations
of G-CSF in relation to TNC counts and various diseases suggests an
important role of G-CSF in the regulation of granulopoiesis during the
neonatal period.
Volume 82,
Issue 10,
pp. 3177-3182,
11/15/1993
Copyright © 1993 by The American Society of Hematology
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